ArticleNature neuroscience2023
A neural substrate of sex-dependent modulation of motivation.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Sex-biased computations underlying differential set shift performance in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neural circuit models for evidence accumulation through choice-selective sequences.Nature communications · 2026Article
- Uncertainty and reward histories have distinct effects on decisions after wins and losses.Scientific reports · 2026Article
- IntelliCage protocols using incentive-disincentive dual motivation work with male as well as female mice and reveal sex differences in motivated behavior.Frontiers in behavioral neuroscience · 2026Article
- Sex differences in task engagement and lapse rate during reward learning.Oxford open neuroscience · 2026Article
- Estrogen modulates reward prediction errors and reinforcement learning.Nature neuroscience · 2025Article
- Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans.Nature neuroscience · 2025Review
- VTA dopamine neuron activity produces spatially organized value representations.bioRxiv : the preprint server for biology · 2025Article
- Striatal pathways oppositely shift cortical activity along the decision axis.bioRxiv : the preprint server for biology · 2025Article
- Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning.Current biology : CB · 2025Article
- Reward integration in prefrontal-cortical and ventral-hippocampal nucleus accumbens inputs cooperatively modulates engagement.Nature communications · 2025Article
- Chronic ethanol exposure produces sex-dependent impairments in value computations in the striatum.Science advances · 2025Article
- A Common Stay-on-Goal Mechanism in the Anterior Cingulate Cortex for Information and Effort Choices.eNeuro · 2025Article
- Interconnected neural circuits mediating social reward.Trends in neurosciences · 2024Review
- A normative framework dissociates need and motivation in hypothalamic neurons.Science advances · 2024Article
- Sex differences in motivational biases over instrumental actions.NPJ science of learning · 2024Article
- Divergent reward cue representations in prefrontal cortex underlie differences in reward motivation between adolescents and adults.bioRxiv : the preprint server for biology · 2024Article
- Sex differences in neural representations of social and nonsocial reward in the medial prefrontal cortex.Nature communications · 2024Article
- A special role for anterior cingulate cortex, but not orbitofrontal cortex or basolateral amygdala, in choices involving information.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Dissociable Contributions of Basolateral Amygdala and Ventrolateral Orbitofrontal Cortex to Flexible Learning Under Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
While there is emerging evidence of sex differences in decision-making behavior, the neural substrates that underlie such differences remain largely unknown. Here we demonstrate that in mice performing a value-based decision-making task, while choices are similar between the sexes, motivation to engage in the task is modulated by action value more strongly in females than in males. Inhibition of activity in anterior cingulate cortex (ACC) neurons that project to the dorsomedial striatum (DMS) preferentially disrupts this relationship between value and motivation in females, without affecting choice in either sex. In line with these effects, in females compared to males, ACC-DMS neurons have stronger representations of negative outcomes and more neurons are active when the value of the chosen option is low. By contrast, the representation of each choice is similar between the sexes. Thus, we identify a neural substrate that contributes to sex-specific modulation of motivation by value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.