Evidence map›Paper›PMID 36646872›Full record

ArticleApplied health economics and health policy2023

Can the UK 'Netflix' Payment Model Boost the Antibacterial Pipeline?

Colm Leonard, Nick Crabb, David Glover, Sophie Cooper, Jacoline Bouvy, Milena Wobbe, Mark Perkins

Abstract read
In one paragraph

Article in Applied health economics and health policy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  16. Global Pull Incentives for Better Antibacterials: The UK Leads the Way.Applied health economics and health policy · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Colm LeonardNational Institute for Health and Care Excellence, Level 1A, City Tower, Manchester, M1 4BT, UK. Colm.Leonard@nice.org.uk.ORCID 0000-0002-6103-4971
Nick CrabbNational Institute for Health and Care Excellence, Level 1A, City Tower, Manchester, M1 4BT, UK.
David GloverNHS England and NHS Improvement, Skipton House, 80 London Road, London, SE1 6LH, UK.
Sophie CooperNational Institute for Health and Care Excellence, Level 1A, City Tower, Manchester, M1 4BT, UK.
Jacoline BouvyNational Institute for Health and Care Excellence, Level 1A, City Tower, Manchester, M1 4BT, UK.
Milena WobbeNational Institute for Health and Care Excellence, Level 1A, City Tower, Manchester, M1 4BT, UK.
Mark PerkinsNHS England and NHS Improvement, Skipton House, 80 London Road, London, SE1 6LH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The silent pandemic of antimicrobial resistance (AMR) is a global issue needing prompt attention. A comprehensive one-health approach across human and animal health, agriculture and the environment is needed to solve this, addressing overuse of antibacterials, and of course, optimising measures for preventing and controlling infection. We also need a robust pipeline of new antibacterials. However, the current pipeline is inadequate and several companies with new antibacterials have gone bankrupt due to low sales, leading to a 'broken market'. To address this, the UK has completed a project using novel approaches to value assessment and reimbursement for two antibacterials. The new funding arrangements for these products commenced on 1st July 2022, delinking reimbursement from volume of sales; a so-called 'pull incentive', with payments based on the added value to the whole-health and social-care system, not just to individual patients. This article describes how the project was devised, developed, and progressed. The learning from this work might help other countries to adopt or adapt the approach to fit with their national systems, and collectively achieve a global incentive to reinvigorate the antibacterial pipeline.

Indexed as

Anti-Bacterial AgentsCommerceAnimalsHumansUnited KingdomAnti-Bacterial Agents

Identifiers

PMID36646872
PMCPMC9842493

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.