ArticleEuropean journal of drug metabolism and pharmacokinetics2023
Relationship Between Dissolution Rate in Vitro and Absorption Rate in Vivo of Ketamine Prolonged-Release Tablets.
Article in European journal of drug metabolism and pharmacokinetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- Dependence of Bioavailability on Mean Absorption Time: What Does It Tell Us?The AAPS journal · 2023Article
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Authors and funding
1 author.
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Abstract
BACKGROUND AND
objectivesUnderstanding the processes that determine the time course of drug absorption rates is of great interest. This study aims to answer the questions: (1) How well can the in vitro dissolution rate predict the in vivo input function (absorption rate) of a prolonged-release ketamine dosage form (PR-ketamine)? (2) Is the information obtained from the in vitro dissolution rate profile useful in estimating bioavailability?
methodsIn vivo plasma concentration data were obtained from 15 healthy volunteers after intravenous and oral dosing of 20 mg PR-ketamine tablets. Both the dissolution and input rates were modeled by a sum of two inverse Gaussian functions.
resultsThe absorption process was dissolution-limited but the mean input time exceeded the mean dissolution time. When the delayed dissolution rate was used to fit the oral data, the estimated bioavailability was nearly identical to that obtained with the full model. The in vitro dissolution rate profile could be used to develop a one-point sampling strategy for predicting bioavailability. According to their fractional rate profiles, dissolution and input rates belong to different classes of functions.
conclusionA comparison of the time course of the absorption rate with that of the dissolution rate can reveal more details of the absorption process.
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