ArticleNature human behaviour2023
Neuronal activity in the human amygdala and hippocampus enhances emotional memory encoding.
Article in Nature human behaviour, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effects of childhood adversity: Two specific neural patterns.Neuroscience and biobehavioral reviews · 2025Pooled it
- Effects of single-modality sensory stimulation on brain function in patients with prolonged disorders of consciousness: a near-infrared spectroscopy-based study.Frontiers in neurology · 2026Trial
- Psychosocial empowerment following orthognathic surgery for patients born with cleft lip and/or palate.International journal of qualitative studies on health and well-being · 2026Article
- Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.iScience · 2026Review
- Hippocampal-cingulate dynamics in the human brain link reinforcement-learning and memory.bioRxiv : the preprint server for biology · 2026Article
- Movement-Anchored Emotional Memory: An Embodied Neuropsychological Framework.Journal of clinical medicine · 2026Review
- Role of the Amygdala in the Complex Relationship Between Sleep and Anxiety.International journal of molecular sciences · 2026Review
- Selective convergence and graded divergence of hippocampal and amygdala subregions using functional connectivity.bioRxiv : the preprint server for biology · 2026Article
- Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Powering the mind: deciphering the shared genetic architecture between mitochondrial DNA copy number and major psychiatric disorders.Molecular psychiatry · 2026Article
- Disgust Propensity, Not Disgust Sensitivity, Shapes the Reactivity of a Subjective Disgust Circuit in Humans.Human brain mapping · 2026Article
- Novelty, Ecological Relevance, and Sexual Receptivity Modulate Neuronal Interactions between the Amygdala and Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Emotional arousal enhances narrative memories through functional integration of large-scale brain networks.Nature human behaviour · 2026Article
- Representational dynamics during extinction of fear memories in the human brain.Nature human behaviour · 2026Article
- Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons.Frontiers in aging neuroscience · 2026Review
- Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder.Frontiers in psychiatry · 2026Article
- Exercise intervention for rumination: from neural mechanisms to clinical applications.Frontiers in psychology · 2026Review
- Article
- Memory in Psychiatric Disorders: A Review.Life (Basel, Switzerland) · 2025Review
- Impacts of early life adversity on the neurocircuitry of emotional memory in children.Development and psychopathology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Emotional events comprise our strongest and most valuable memories. Here we examined how the brain prioritizes emotional information for storage using direct brain recording and deep brain stimulation. First, 148 participants undergoing intracranial electroencephalographic (iEEG) recording performed an episodic memory task. Participants were most successful at remembering emotionally arousing stimuli. High-frequency activity (HFA), a correlate of neuronal spiking activity, increased in both the hippocampus and the amygdala when participants successfully encoded emotional stimuli. Next, in a subset of participants (N = 19), we show that applying high-frequency electrical stimulation to the hippocampus selectively diminished memory for emotional stimuli and specifically decreased HFA. Finally, we show that individuals with depression (N = 19) also exhibit diminished emotion-mediated memory and HFA. By demonstrating how direct stimulation and symptoms of depression unlink HFA, emotion and memory, we show the causal and translational potential of neural activity in the amygdalohippocampal circuit for prioritizing emotionally arousing memories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.