Evidence map›Paper›PMID 36646808›Full record

ArticleBritish journal of cancer2023

High-throughput precision MRI assessment with integrated stack-ensemble deep learning can enhance the preoperative prediction of prostate cancer Gleason grade.

Jie Bao, Ying Hou, Lang Qin, Rui Zhi, Xi-Ming Wang, Hai-Bin Shi, Hong-Zan Sun, Chun-Hong Hu, Yu-Dong Zhang

Abstract read
In one paragraph

Article in British journal of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jie Bao *Department of Radiology, The First Affiliated Hospital of Soochow University, 188N, Shizi Road, 215006, Suzhou, Jiangsu, China.
Ying Hou *Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300N, Guangzhou Road, 210029, Nanjing, Jiangsu, China.
Lang QinDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300N, Guangzhou Road, 210029, Nanjing, Jiangsu, China.
Rui ZhiDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300N, Guangzhou Road, 210029, Nanjing, Jiangsu, China.
Xi-Ming WangDepartment of Radiology, The First Affiliated Hospital of Soochow University, 188N, Shizi Road, 215006, Suzhou, Jiangsu, China.
Hai-Bin ShiDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300N, Guangzhou Road, 210029, Nanjing, Jiangsu, China.
Hong-Zan SunDepartment of Radiology, Shengjing Hospital of China Medical University, Shenyang, China. sunhongzan@126.com.
Chun-Hong HuDepartment of Radiology, The First Affiliated Hospital of Soochow University, 188N, Shizi Road, 215006, Suzhou, Jiangsu, China. hch5305@163.com.
Yu-Dong ZhangDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300N, Guangzhou Road, 210029, Nanjing, Jiangsu, China. zhangyd3895@njmu.edu.cn.ORCID 0000-0002-2811-7513

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo develop and test a Prostate Imaging Stratification Risk (PRISK) tool for precisely assessing the International Society of Urological Pathology Gleason grade (ISUP-GG) of prostate cancer (PCa).

methodsThis study included 1442 patients with prostate biopsy from two centres (training, n = 672; internal test, n = 231 and external test, n = 539). PRISK is designed to classify ISUP-GG 0 (benign), ISUP-GG 1, ISUP-GG 2, ISUP-GG 3 and ISUP GG 4/5. Clinical indicators and high-throughput MRI features of PCa were integrated and modelled with hybrid stacked-ensemble learning algorithms.

resultsPRISK achieved a macro area-under-curve of 0.783, 0.798 and 0.762 for the classification of ISUP-GGs in training, internal and external test data. Permitting error ±1 in grading ISUP-GGs, the overall accuracy of PRISK is nearly comparable to invasive biopsy (train: 85.1% vs 88.7%; internal test: 85.1% vs 90.4%; external test: 90.4% vs 94.2%). PSA ≥ 20 ng/ml (odds ratio [OR], 1.58; p = 0.001) and PRISK ≥ GG 3 (OR, 1.45; p = 0.005) were two independent predictors of biochemical recurrence (BCR)-free survival, with a C-index of 0.76 (95% CI, 0.73-0.79) for BCR-free survival prediction.

conclusionsPRISK might offer a potential alternative to non-invasively assess ISUP-GG of PCa.

Indexed as

Deep LearningProstatic NeoplasmsHumansMagnetic Resonance ImagingMaleNeoplasm GradingProstate

Identifiers

PMID36646808
PMCPMC10050457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.