Trial reportNature medicine2023
[
Registry-linked trialOpen access · hybridAbstract readClinical Trial
In one paragraph
Trial report in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02945904 (IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism), which is not on this map. Cited by 69 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 6 pooled it
25.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism
Who cites it
69 citing papers in PubMed, 6 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Agreement Between Molecular Imaging and Adrenal Vein Sampling for Localization in Primary Aldosteronism: A Systematic Review.Journal of the American Heart Association · 2026Pooled it
- AVS-referenced diagnostic performance ofFrontiers in endocrinology · 2026Pooled it
- Guideline
- Tools to Predict Unilateral Primary Aldosteronism and Optimise Patient Selection for Adrenal Vein Sampling: A Systematic Review.Clinical endocrinology · 2025Pooled it
- Adrenal Vein Sampling for Primary Aldosteronism: Recommendations From the Australian and New Zealand Working Group.Clinical endocrinology · 2025Guideline
- Time to Benefit of Surgery vs Targeted Medical Therapy for Patients With Primary Aldosteronism: A Meta-analysis.The Journal of clinical endocrinology and metabolism · 2024Pooled it
- Evaluation of Aldosterone Suppression by Cinnarizine, a Putative Cav1.3 Inhibitor.The Journal of clinical endocrinology and metabolism · 2025Trial
- Aldosterone-Producing Lesions HarboringHypertension (Dallas, Tex. : 1979) · 2026Article
- 18F-CETO in adrenocortical carcinoma: first clinical-translational study of an adrenocortical-targeting PET tracer.Endocrine-related cancer · 2026Article
- DeltaAnnals of surgical oncology · 2026Article
- From bench to bedside: primary aldosteronism revisited.Endocrine connections · 2026Article
- Apparent Bilateral Aldosterone Suppression During Adrenal Vein Sampling: An Artefact of the Liaison Chemiluminescence Immunoassay and Other Causes Revealed by Comparisons With Another Commercial Immunoassay and Mass Spectrometry.Clinical endocrinology · 2026Observational
- Bilateral Adrenal Primary Aldosteronism Is Uniformly Present in Hypertensive Afro-Caribbean First-Generation Immigrants to Western Canada.Journal of the American Heart Association · 2026Article
- Primary aldosteronism.Nature reviews. Disease primers · 2026Review
- Molecular Imaging in Primary Aldosteronism Subtyping: A Promising Complement but Not Yet a Replacement for Adrenal Venous Sampling.Journal of the American Heart Association · 2026Article
- Diagnostic value of short-duration head-up tilt test for unexplained syncope: a non-inferiority study.BMC cardiovascular disorders · 2026Article
- [Novel imaging techniques for the differential diagnosis of adrenal tumors, pheochromocytomas and paragangliomas].Chirurgie (Heidelberg, Germany) · 2026Review
- ⁶⁸GA-Pentixafor PET/CT: a non-invasive molecular alternative to adrenal venous sampling in primary aldosteronism.EJNMMI reports · 2026Review
- Molecular pathology of primary aldosteronism and hypercortisolism: Impact on adrenal surgery.iScience · 2026Review
- Preferences for Subtyping Primary Aldosteronism: A Discrete Choice Experiment.Journal of the Endocrine Society · 2026Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
42 authors at 10 institutions in 2 countries.
Xilin WuEndocrine Hypertension, Department of Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.ORCID http://orcid.org/0000-0002-8487-9942
Russell Senanayake *Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Emily Goodchild *Endocrine Hypertension, Department of Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Waiel A BashariMetabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Jackie SalsburyEndocrine Hypertension, Department of Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Claudia P CabreraCentre for Translational Bioinformatics, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.ORCID http://orcid.org/0000-0002-2205-5315
Giulia ArgentesiEndocrine Hypertension, Department of Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Samuel M O'TooleEndocrine Hypertension, Department of Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.ORCID http://orcid.org/0000-0002-8943-8556
Matthew MatsonDepartment of Radiology, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom.
Brendan KooDepartment of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Laila ParvantaDepartment of Endocrinology, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom.
Nick HilliardDepartment of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Vasilis KosmoliaptsisDepartment of Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.ORCID http://orcid.org/0000-0001-7298-1387
Alison MarkerDepartment of Histopathology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Daniel M BerneyDepartment of Histopathology, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom.ORCID http://orcid.org/0000-0001-5474-8696
Wilson TanCardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Roger FooCardiovascular Research Institute, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-8079-4618
Charles A MeinBarts and the London Genome Centre, School of Medicine and Dentistry, Blizard Institute, London, United Kingdom.
Eva WozniakBarts and the London Genome Centre, School of Medicine and Dentistry, Blizard Institute, London, United Kingdom.
Emmanuel SavageBarts and the London Genome Centre, School of Medicine and Dentistry, Blizard Institute, London, United Kingdom.
Anju SahdevDepartment of Radiology, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom.ORCID http://orcid.org/0000-0001-8520-3031
Nicholas BirdDepartment of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Kate LaycockEndocrine Hypertension, Department of Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Istvan BorosWolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom.
Stefan HaderWolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom.
Victoria WarnesDepartment of Nuclear Medicine, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Daniel GillettDepartment of Nuclear Medicine, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Anne DawnayDepartment of Clinical Biochemistry, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom.ORCID http://orcid.org/0000-0001-6674-5986
Elizabeth AdeyeyeDepartment of Cardiovascular Medicine/Diabetes, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Alessandro PreteInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.
Angela E TaylorInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.
Wiebke ArltInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.ORCID http://orcid.org/0000-0001-5106-9719
Anish N BhuvaDepartment of Cardiology, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom.ORCID http://orcid.org/0000-0001-7532-7815
Franklin AigbirhioWolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom.
Charlotte ManistyDepartment of Cardiology, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom.
Alasdair McIntoshRobertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom.ORCID http://orcid.org/0000-0003-2534-8647
Alexander McConnachieRobertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom.ORCID http://orcid.org/0000-0002-7262-7000
J Kennedy CruickshankDepartment of Cardiovascular Medicine/Diabetes, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Heok CheowDepartment of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Mark Gurnell *Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
William M Drake *NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Morris J Brown *Endocrine Hypertension, Department of Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom. morris.brown@qmul.ac.uk.ORCID http://orcid.org/0000-0001-8409-1082
St Bartholomew's Hospital · GBCambridge University Hospitals NHS Foundation Trust · GBQueen Mary University of London · GBUniversity of Cambridge · GBNational University of Singapore · SGUniversity of Birmingham · GBUniversity of Glasgow · GBGuy's and St Thomas' NHS Foundation Trust · GBKing's College London · GBUniversity Hospitals Birmingham NHS Foundation Trust · GB
Funding
British Heart Foundation FS/19/50/34566Department of Health 14/145/09Department of Health BRC-1215-20009Department of Health IS-BRC-1215-20014Department of Health IS-BRC-1215-20022Medical Research Council MC_UP_1605/15Medical Research Council MR/P01710X/1Medical Research Council MR/S006869/1
Abstract
Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery. However, the invasive nature of the standard pre-surgical investigation contributes to fewer than 1% of patients with PA being offered the chance of a cure. The primary objective of our prospective study of 143 patients with PA ( NCT02945904 ) was to compare the accuracy of a non-invasive test, [
Indexed as
HyperaldosteronismPositron Emission Tomography Computed TomographyAdrenal GlandsEtomidateHumansProspective StudiesRetrospective StudiesEtomidatemetomidate
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT02945904ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.