ArticleNature communications2023
The metabolite alpha-ketobutyrate extends lifespan by promoting peroxisomal function in C. elegans.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
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- Vitamin K2 Extends Lifespan by Alleviating Mitochondrial Stress via the JNK-1/SIR-2.1/DAF-16 Signaling Axis in Caenorhabditis elegans.Aging cell · 2026Article
- Reconstructing mammalian lifespan evolution reveals strong phylogenetic effects and lifespan-associated genes.BMC biology · 2026Article
- Review
- Enhanced oxidative stress resilience inExperimental biology and medicine (Maywood, N.J.) · 2026Article
- Association of plasma metabolites with epigenetic age acceleration: a two-sample Mendelian randomization study.Biogerontology · 2025Article
- Matrine Inhibits High-Glucose-Diet-Induced Fat Accumulation and Aβ-Mediated Lipid Metabolic Disorder via AAK-2/NHR-49 Pathway inInternational journal of molecular sciences · 2025Article
- Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin.GeroScience · 2024Article
- Metabolic Pathways Affected in Patients Undergoing Hemodialysis and Their Relationship with Inflammation.International journal of molecular sciences · 2024Article
- The role of serum-glucocorticoid regulated kinase 1 in reproductive viability: implications from prenatal programming and senescence.Molecular biology reports · 2024Review
- Assessing the associations of 1,400 blood metabolites with major depressive disorder: a Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Disrupting the SKN-1 homeostat: mechanistic insights and phenotypic outcomes.Frontiers in aging · 2024Review
- The million-molecule challenge: a moonshot project to rapidly advance longevity intervention discovery.GeroScience · 2023Article
- Acyl CoA oxidase: from its expression, structure, folding, and import to its role in human health and disease.Molecular genetics and genomics : MGG · 2023Review
- Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans.Nature communications · 2023Article
- 2 Hydroxybutyric Acid-Producing Bacteria in Gut Microbiome andMetabolites · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Metabolism is intimately linked to aging. There is a growing number of studies showing that endogenous metabolites may delay aging and improve healthspan. Through the analysis of existing transcriptome data, we discover a link between activation of the transsulfuration pathway and a transcriptional program involved in peroxisome function and biogenesis in long-lived glp-1(e2141ts) mutant Caenorhabditis elegans worms. Subsequently, we show that supplementation with α-ketobutyrate, an intermediate of the transsulfuration pathway, extends lifespan in wild-type worms. Alpha-ketobutyrate augments the production of NAD
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