Evidence map›Paper›PMID 36646509›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Single Atom-Doped Nanosonosensitizers for Mutually Optimized Sono/Chemo-Nanodynamic Therapy of Triple Negative Breast Cancer.

Qiqing Chen, Min Zhang, Hui Huang, Caihong Dong, Xinyue Dai, Guiying Feng, Ling Lin, Dandan Sun, Dayan Yang, Lin Xie and 3 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Emerging copper-based hollow nanoplatforms for cancer treatment.International journal of pharmaceutics: X · 2026
    Review
  2. FeiScience · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. A BiInternational journal of nanomedicine · 2025
    Article
  13. Enhanced Sonodynamic Therapy via Au Nanoclusters Deposited on TiOInternational journal of nanomedicine · 2025
    Article
  14. Review
  15. Self-Assembled Aza-Boron-Dipyrromethene-Based HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qiqing ChenDepartment of Ultrasonography, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, P. R. China.
Min ZhangDepartment of Ultrasonography, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, P. R. China.
Hui HuangMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, P. R. China.
Caihong DongDepartment of Ultrasound, Zhongshan Hospital, Fudan University, and Shanghai Institute of Medical Imaging, Shanghai, 200032, P. R. China.
Xinyue DaiMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, P. R. China.
Guiying FengDepartment of Ultrasonography, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, P. R. China.
Ling LinDepartment of Ultrasonography, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, P. R. China.
Dandan SunDepartment of Ultrasonography, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, P. R. China.
Dayan YangDepartment of Ultrasonography, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, P. R. China.
Lin XieDepartment of Ultrasonography, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, P. R. China.
Yu ChenMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, P. R. China.ORCID 0000-0002-8206-3325
Jia GuoShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P. R. China.
Xiangxiang JingDepartment of Ultrasonography, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, P. R. China.

Funding

Basic Research Program of Shanghai Municipal Government 21JC1406002Hainan Province Science and Technology Special Fund ZDYF2019136Hainan Province Science and Technology Special Fund ZDYF2020138Hainan Province Science and Technology Special Fund ZDYF2020140National Natural Science Foundation of China 81760317National Natural Science Foundation of China 81871365National Natural Science Foundation of China 82160337Shanghai Science and Technology Program 21010500100Shanghai Science and Technology Program 22140901700Shanghai Science and Technology Program 22142202200Shanghai Science and Technology Program 22DZ2204700
6 · The paper itself

Abstract

Sonodynamic therapy (SDT) represents a promising therapeutic modality for treating breast cancer, which relies on the generation of abundant reactive oxygen species (ROS) to induce oxidative stress damage. However, mutant breast cancers, especially triple-negative breast cancer (TNBC), have evolved to acquire specific antioxidant defense functions, significantly limiting the killing efficiency of SDT. Herein, the authors have engineered a distinct single copper atom-doped titanium dioxide (Cu/TiO

Indexed as

Triple Negative Breast NeoplasmsUltrasonic TherapyHumansReactive Oxygen SpeciesTitaniumReactive Oxygen SpeciesTitaniumtitanium dioxidechemodynamic therapysingle-atom catalysissonodynamic therapytriple-negative breast cancer therapy

Identifiers

PMID36646509
PMCPMC9951334

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.