Evidence map›Paper›PMID 36645710›Full record

ArticleCancer2023

Emotional, behavioral, and physical health consequences of loneliness in young adult survivors of childhood cancer: Results from the Childhood Cancer Survivor Study.

Chiara Papini, Ameera A Fayad, Mingjuan Wang, Fiona S M Schulte, I-Chan Huang, Yu-Ping Chang, Rebecca M Howell, Deokumar Srivastava, Wendy M Leisenring, Gregory T Armstrong and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Implementing health promotion interventions in a pediatric oncology setting: A qualitative study among families impacted by cancer and healthcare professionals.Journal of child health care : for professionals working with children in the hospital and community · 2026
    Article
  5. Article
  6. Social information processing in survivors of pediatric brain tumors.Journal of cancer survivorship : research and practice · 2026
    Article
  7. The association between loneliness and quality of life in cancer survivors: All of Us research program.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Metabolic Implications of Childhood Cancer.Current pediatrics reports · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Chiara PapiniDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-5338-4154
Ameera A FayadSchool of Nursing, Washington State University, Seattle, Washington, USA.
Mingjuan WangDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Fiona S M SchulteDepartment of Psychology, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-3076-9676
I-Chan HuangDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-1194-3923
Yu-Ping ChangUniversity at Buffalo School of Nursing, The State University of New York, New York, New York, USA.
Rebecca M HowellDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Deokumar SrivastavaDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Wendy M LeisenringClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.ORCID 0000-0001-7405-0906
Gregory T ArmstrongDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Todd M GibsonNational Cancer Institute, Bethesda, Maryland, USA.
Leslie L RobisonDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kevin C OeffingerDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Kevin R KrullDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-0476-7001
Tara M BrinkmanDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-4250-6160
St. Jude Children's Research Hospital · USDuke University · USFred Hutch Cancer Center · USNational Cancer Institute · USThe University of Texas MD Anderson Cancer Center · USUniversity at Buffalo, State University of New York · USUniversity of Calgary · CAWashington State University Vancouver · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Laura Fish · 1985 to 2026
$174.8M
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
NCATS NIH HHS UL1 TR001412NCI NIH HHS P30 CA014236NCI NIH HHS P30 CA021765NCI NIH HHS U24 CA055727
6 · The paper itself

Abstract

backgroundYoung adults in the general population are at risk of experiencing loneliness, which has been associated with physical and mental health morbidities. The prevalence and consequences of loneliness in young adult survivors of childhood cancer remain unknown.

methodsA total of 9664 young adult survivors of childhood cancer (median age at diagnosis 10.5 years [interquartile range (IQR), 5-15], 27.1 years at baseline [IQR, 23-32]) and 2221 siblings enrolled in the Childhood Cancer Survivor Study completed a self-reported survey question assessing loneliness on the Brief Symptom Inventory-18 at baseline and follow-up (median follow-up, 6.6 years). Multivariable models evaluated the prevalence of loneliness at baseline only, follow-up only, and baseline + follow-up, and its associations with emotional distress, health behaviors, and chronic conditions at follow-up.

resultsSurvivors were more likely than siblings to report loneliness at baseline + follow-up (prevalence ratio [PR] 2.2; 95% confidence interval [CI], 1.7-3.0) and at follow-up only (PR, 1.4; 95% CI, 1.1-1.7). Loneliness at baseline + follow-up was associated with elevated risk of anxiety (relative risk [RR], 9.8; 95% CI, 7.5-12.7), depression (RR, 17.9; 95% CI, 14.1-22.7), and current smoking (odds ratio [OR], 1.7; 95% CI, 1.3-2.3) at follow-up. Loneliness at follow-up only was associated with suicidal ideation (RR, 1.5; 95% CI, 1.1-2.1), heavy/risky alcohol consumption (RR, 1.3; 95% CI, 1.1-1.5), and new-onset grade 2-4 chronic conditions (RR, 1.3; 95% CI, 1.0-1.7).

conclusionsYoung adult survivors of childhood cancer have elevated risk of experiencing loneliness, which is associated with future emotional distress, risky health behaviors, and new-onset chronic conditions.

Indexed as

Cancer SurvivorsNeoplasmsChildChronic DiseaseHumansLonelinessRisk FactorsSurvivorsYoung Adultchildhood cancerlonelinessquality of lifesurvivorshipyoung adult

Identifiers

PMID36645710
PMCPMC9998368
OpenAlexW4316496299

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.