Evidence map›Paper›PMID 36645524›Full record

ArticleInternational journal of colorectal disease2023

High-intensity mechanical bowel preparation before curative colorectal surgery is associated with poor long-term prognosis.

Zhiqiang Li, Yanpeng Chu, Zhengfei Zhao, Jiangping Fu, Qingjuan Peng, Jun Zhang, Biao Wang, Xiufang Luo, Zhi Huang, Linguang Fan and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of colorectal disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Zhiqiang Li *Pediatric Surgery Department, Dazhou Central Hospital, Dazhou, China.
Yanpeng Chu *Medical College, Sichuan University of Arts and Science, Dazhou, China.
Zhengfei Zhao *Department of Gastrointestinal Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Jiangping Fu *Oncology Department, Dazhou Central Hospital, Dazhou, China.
Qingjuan PengTraditional Chinese Medicine Rehabilitation Department, Dazhou Central Hospital, Dazhou, China.
Jun ZhangDepartment of General Surgery, Dazhou Central Hospital, Tongchuan District, No.56 Nanyuemiao Street, Sichuan Province, Dazhou, China.
Biao WangDepartment of General Surgery, Dazhou Central Hospital, Tongchuan District, No.56 Nanyuemiao Street, Sichuan Province, Dazhou, China.
Xiufang LuoDepartment of Geriatric, Dazhou Central Hospital, Dazhou, China.
Zhi HuangDepartment of General Surgery, Dazhou Central Hospital, Tongchuan District, No.56 Nanyuemiao Street, Sichuan Province, Dazhou, China.
Linguang FanDepartment of General Surgery, Dazhou Central Hospital, Tongchuan District, No.56 Nanyuemiao Street, Sichuan Province, Dazhou, China.
Jie LiuDepartment of General Surgery, Dazhou Central Hospital, Tongchuan District, No.56 Nanyuemiao Street, Sichuan Province, Dazhou, China. 123574514@qq.com.
Dazhou Central Hospital · CNAffiliated Hospital of Southwest Medical University · CNSichuan University of Arts and Science · CN

Funding

Dazhou Science and Technology Bureau project 21ZDYF0023Dazhou Science and Technology Bureau project 21ZDYF0025Sichuan Medical Association Project S21048
6 · The paper itself

Abstract

purposeMechanical bowel preparation (MBP) has been widely used to reduce intestinal feces and bacteria and is considered necessary to prevent surgical infections. However, it is still controversial which intensity level of MBP is the most beneficial for patients before colorectal surgery. Our study aimed to determine the impact of different intensity levels of MBP on the progression-free survival (PFS) and overall survival (OS) for colorectal cancer (CRC) patients.

methodsWe evaluated 694 patients pathologically diagnosed with CRC and underwent MBP before surgery at 4 general hospitals from January 2011 to December 2015. The survival status of patients, the disease progression, and the time of death or progression were obtained through telephone follow-up at the deadline October 10, 2018. Hazard ratios were estimated by Cox proportional hazard models. Survival was assessed using the Kaplan-Meier method followed by the log-rank test.

resultsOf 694 patients included, 462 received low-intensity MBP and 232 received high-intensity MBP. A significantly higher PFS in low-intensity MBP was observed (p = 0.009). PFS at 2000 days was 69.331% in the low-intensity arm and 58.717% in the high-intensity arm. Patients who underwent low-intensity MBP also showed higher OS (p = 0.009). Nine patients in the low-intensity MBP group received secondary surgery, and two patients in the high-intensity MBP group received secondary surgery.

conclusionsIn this retrospective cohort, low-intensity MBP was associated with better PFS and OS, which could provide a reference for doctors when choosing the intensity of MBP.

Indexed as

Colorectal NeoplasmsColorectal SurgeryDigestive System Surgical ProceduresHumansPreoperative CarePrognosisRetrospective StudiesSurgical Wound InfectionColorectal cancerMechanical bowel preparationOverall survivalProgression-free survival

Identifiers

PMID36645524
OpenAlexW4316465131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.