ArticleArchives of toxicology2023
A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe.
Article in Archives of toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed.
- Applicability of NAMs to support a read-across based hazard assessment workflow for systemic toxicity: a conazole case study.Archives of toxicology · 2026Article
- Validated SPE-HPLC-MS/MS analysis of steroid hormones in H295R cell culture medium: chromatographic separation and ESI response in the presence of potential endocrine-disrupting chemicals.Analytical and bioanalytical chemistry · 2026Article
- Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Classification of Thyroid Peroxidase (TPO) Inhibitors Using Transfer Learning with SMILES Embeddings.Chemical research in toxicology · 2026Article
- Public Views on Pesticide Exposure and Human Biomonitoring in Latvia: Evidence from Focus Groups and Media Analysis.Toxics · 2026Article
- Bridging the life-course exposome approach with a life-cycle perspective in safe and sustainable by design (SSbD) for chemical risk.Human genomics · 2026Article
- A new multi-residue method for PFAS analysis in wastewater for environmental and public health risk assessment.Analytical and bioanalytical chemistry · 2026Article
- Regulation of chemicals demands assessment of risks rather than identification of hazards only.Archives of toxicology · 2026Article
- Prediction of relevant exposure sources to aggregate chemical exposures from general and occupational environments: exploration of a decision tree approach.Annals of work exposures and health · 2026Article
- From prioritization to implementation: updating the PARC WP5 project portfolio through the second prioritization round.Frontiers in toxicology · 2026Review
- New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption - a PARC project.Frontiers in toxicology · 2026Review
- Shaping the future of human biomonitoring (HBM): progress, strategy, and global vision from ISES Europe and the HBM Global Network.Environment international · 2026Article
- ASPIS Academy: A blueprint for building early-career researcher networks to advance NAM-based risk assessment.NAM journal · 2026Article
- Editorial: European partnership on the assessment of risks from chemicals (PARC): continued focus on new approach methodologies (NAMs) and data gap filling.Frontiers in toxicology · 2026Article
- Preventing regrettable substitutions: a proposal for a tiered testing approach for BPA alternatives under the PARC initiative.Frontiers in toxicology · 2026Article
- ARACRA: Automated RNA-seq Analysis for Chemical Risk Assessment.Computational and structural biotechnology journal · 2026Article
- The data substrate of exposome intelligence: an interoperability profile for untargeted metabolomics.Frontiers in artificial intelligence · 2026Article
- Computational characterisation of ecological hazard and risk of environmental mixtures.EFSA journal. European Food Safety Authority · 2025Article
- Advancing the One Health Framework in EU Plant Protection Product Regulation: Challenges and Opportunities.Journal of xenobiotics · 2025Article
- Human biomonitoring of essential and toxic trace elements (heavy metals and metalloids) in urine of children, teenagers, and young adults from a Central European Cohort in the Czech Republic.Journal of exposure science & environmental epidemiology · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors.
Funding
Abstract
Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical risk assessment and explorations of how to translate these concepts into pragmatic approaches. As a result, next-generation risk assessment (NGRA) is generally seen as the way forward. However, incorporating new scientific insights and innovative approaches into hazard and exposure assessments in such a way that regulatory needs are adequately met has appeared to be challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) has been designed to address various challenges associated with innovating chemical risk assessment. Its overall goal is to consolidate and strengthen the European research and innovation capacity for chemical risk assessment to protect human health and the environment. With around 200 participating organisations from all over Europe, including three European agencies, and a total budget of over 400 million euro, PARC is one of the largest projects of its kind. It has a duration of seven years and is coordinated by ANSES, the French Agency for Food, Environmental and Occupational Health & Safety.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.