Evidence map›Paper›PMID 36645410›Full record

ArticleeLife2023

Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts.

Richard C Lauer, Marc Barry, Tracey L Smith, Andrew Maltez Thomas, Jin Wu, Ruofei Du, Ji-Hyun Lee, Arpit Rao, Andrey S Dobroff, Marco A Arap and 8 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 4 countries.

Richard C Lauer *University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States.
Marc Barry *Department of Pathology, University of Utah, Salt Lake City, Utah, United States.
Tracey L SmithRutgers Cancer Institute of New Jersey, Newark, New Jersey, United States.
Andrew Maltez ThomasDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.ORCID 0000-0001-5789-3354
Jin WuUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States.
Ruofei DuDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.
Ji-Hyun LeeDepartment of Biostatistics, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-6420-5150
Arpit RaoSection of Hematology and Oncology, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States.
Andrey S DobroffUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States.
Marco A ArapDivision of Urology, University of São Paulo Medical School, São Paulo, Brazil.
Diana N NunesLaboratory of Medical Genomics, A.C. Camargo Cancer Center, São Paulo, Brazil.
Israel T SilvaLaboratory of Bioinformatics and Computational Biology, A.C. Camargo Cancer Center, São Paulo, Brazil.
Emmanuel Dias-NetoLaboratory of Medical Genomics, A.C. Camargo Cancer Center, São Paulo, Brazil.
Isan ChenMBrace Therapeutics, San Diego, California, United States.
Dennis J McCanceUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States.
Webster K CaveneeLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, California, United States.
Renata PasqualiniRutgers Cancer Institute of New Jersey, Newark, New Jersey, United States.
Wadih ArapRutgers Cancer Institute of New Jersey, Newark, New Jersey, United States.ORCID 0000-0002-8686-4584
University of New Mexico · USAC Camargo Hospital · BRRutgers, The State University of New Jersey · USUniversidade de São Paulo · BRBaylor College of Medicine · USLudwig Cancer Research · USUniversity of Arkansas for Medical Sciences · USUniversity of Florida Health · USUniversity of Utah · US

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
NCI NIH HHS P30 CA072720NCI NIH HHS P30CA072720NCI NIH HHS P30 CA118100NCI NIH HHS P30CA118100
6 · The paper itself

Abstract

Background: We have previously shown that the long non-coding (lnc)RNA Methods: The reciprocal Results: We consistently observed increased expression of Conclusions: We concluded that upregulation of the lncRNA Funding: We received support from the Human Tissue Repository and Tissue Analysis Shared Resource from the Department of Pathology of the University of New Mexico School of Medicine and a pilot award from the University of New Mexico Comprehensive Cancer Center. RP and WA were supported by awards from the Levy-Longenbaugh Donor-Advised Fund and the Prostate Cancer Foundation. EDN reports research fellowship support from the Brazilian National Council for Scientific and Technological Development (CNPq), Brazil, and the Associação Beneficente Alzira Denise Hertzog Silva (ABADHS), Brazil. This work has been funded in part by the NCI Cancer Center Support Grants (CCSG; P30) to the University of New Mexico Comprehensive Cancer Center (CA118100) and the Rutgers Cancer Institute of New Jersey (CA072720).

Indexed as

Prostatic NeoplasmsRNA, Long NoncodingAntigens, NeoplasmBiomarkers, TumorHumansMaleNeoplasm ProteinsNeoplasm Recurrence, LocalProstateRetrospective StudiesAntigens, NeoplasmBiomarkers, TumorNeoplasm ProteinsPRUNE2 protein, humanRNA, Long Noncodinghumanlong non-coding RNAmedicineoncogenePCA3prostate cancerPRUNE2tumor suppressor gene

Identifiers

PMID36645410
PMCPMC9886275
OpenAlexW4316494491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.