Evidence map›Paper›PMID 36645408›Full record

ArticleeLife2023

Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14).

Guang Lin, Burak Tepe, Geoff McGrane, Regine C Tipon, Gist Croft, Leena Panwala, Amanda Hope, Agnes J H Liang, Zhongyuan Zuo, Seul Kee Byeon and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  9. Sphingolipids in neurodegenerative diseases.Frontiers in neuroscience · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Guang LinDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0001-5594-3397
Burak TepeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0003-4371-2502
Geoff McGraneNew York Stem Cell Foundation Research Institute, New York, United States.
Regine C TiponNew York Stem Cell Foundation Research Institute, New York, United States.ORCID 0000-0002-5473-7353
Gist CroftNew York Stem Cell Foundation Research Institute, New York, United States.
Leena PanwalaINADcure Foundation, Jersey City, United States.
Amanda HopeINADcure Foundation, Jersey City, United States.
Agnes J H LiangDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Zhongyuan ZuoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Seul Kee ByeonDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States.
Lily WangDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Akhilesh PandeyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States.ORCID 0000-0001-9943-6127
Hugo J BellenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0001-5992-5989
Baylor College of Medicine · USNew York Stem Cell Foundation · USManipal Academy of Higher Education · INMayo Clinic in Arizona · US

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
NICHD NIH HHS P50 HD103555NIH HHS P50HD103555
6 · The paper itself

Abstract

Infantile neuroaxonal dystrophy (INAD) is caused by recessive variants in

Indexed as

Drosophila ProteinsNeuroaxonal DystrophiesParkinsonian DisordersAnimalsCeramidesDrosophilaDystonic DisordersEye ProteinsGroup VI Phospholipases A2MiceNeuronsCeramidesDrosophila ProteinsEye ProteinsGroup VI Phospholipases A2inaD protein, DrosophilaPla2g6 protein, mouseadeno-associated virusceramidesdopaminergic neuronsdrosophiladrug screengene therapyINADipsclysosomemiceneural progenitor cellsneuroscienceParkinson's disease

Identifiers

PMID36645408
PMCPMC9889087
OpenAlexW4316661828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.