Evidence map›Paper›PMID 36645301›Full record

ArticlemBio2023

LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus.

Vaiva Gradauskaite, Marine Inglebert, John Doench, Melanie Scherer, Martina Dettwiler, Marianne Wyss, Neeta Shrestha, Sven Rottenberg, Philippe Plattet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Vaiva Gradauskaite *Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Marine Inglebert *Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
John DoenchGenetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Melanie SchererDivision of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Martina DettwilerInstitute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Marianne WyssDivision of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Neeta ShresthaDivision of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Sven Rottenberg *Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Philippe Plattet *Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.ORCID 0000-0003-3313-2598
University of Bern · CHBroad Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wild-type canine distemper virus (CDV) is an important pathogen of dogs as well as wildlife that can infect immune and epithelial cells through two known receptors: the signaling lymphocytic activation molecule (SLAM) and nectin-4, respectively. Conversely, the ferret and egg-adapted CDV-Onderstepoort strain (CDV-OP) is employed as an effective vaccine for dogs. CDV-OP also exhibits promising oncolytic properties, such as its abilities to infect and kill multiple cancer cells

Indexed as

DistemperDistemper Virus, CanineAnimalsCell Adhesion MoleculesDogsFerretsLow Density Lipoprotein Receptor-Related Protein-6NectinsReceptors, VirusCell Adhesion MoleculesLow Density Lipoprotein Receptor-Related Protein-6NectinsReceptors, Virusattenuated CDVcell entryCRISPR/Cas9 KO screenLRP6receptor

Identifiers

PMID36645301
PMCPMC9973313
OpenAlexW4316662985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.