Evidence map›Paper›PMID 36645064›Full record

ArticleChemical communications (Cambridge, England)2023

Carrier protein mediated cargo sensing in quorum signal synthases.

Patrick D Fischer, Abu Sayeed Chowdhury, Thomas Bartholow, Shibani Basu, Eric Baggs, Huel S Cox, Srđan Matošin, Michael D Burkart, Lisa Warner, Rajesh Nagarajan and 1 more

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Biomolecular NMR assignments · 2023
    Article
  2. BackboneBiomolecular NMR assignments · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Patrick D FischerDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. hari@hms.harvard.edu.
Abu Sayeed ChowdhuryBiomolecular Sciences Graduate Program, Boise State University, Boise, ID, USA.ORCID http://orcid.org/0000-0002-1331-9665
Thomas BartholowDepartment of Chemistry and Biochemistry, University of California, San Diego, CA, USA.
Shibani BasuDepartment of Chemistry and Biochemistry, Boise State University, Boise, ID, USA. rajnagarajan@boisestate.edu.ORCID http://orcid.org/0000-0001-5018-5478
Eric BaggsDepartment of Chemistry and Biochemistry, Boise State University, Boise, ID, USA. rajnagarajan@boisestate.edu.
Huel S CoxDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. hari@hms.harvard.edu.
Srđan MatošinDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. hari@hms.harvard.edu.
Michael D BurkartDepartment of Chemistry and Biochemistry, University of California, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-4472-2254
Lisa WarnerDepartment of Chemistry and Biochemistry, Boise State University, Boise, ID, USA. rajnagarajan@boisestate.edu.
Rajesh NagarajanDepartment of Chemistry and Biochemistry, Boise State University, Boise, ID, USA. rajnagarajan@boisestate.edu.ORCID http://orcid.org/0000-0001-5548-9972
Haribabu ArthanariDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. hari@hms.harvard.edu.ORCID http://orcid.org/0000-0002-7281-1289
Boise State University · USHarvard University · USUniversity of California San Diego · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Carolyn Hovde Bohach · 2012 to 2026
$59.8M
UNDERGRADUATE COLLEGE OUTREACH PROGRAMP20RR016454 · NCRR · UNIVERSITY OF IDAHO · PI HOVDE, CAROLYN J · 2001 to 2011
$35.3M
Protein-Protein Interactions in Natural Product BiosynthesisR01GM095970 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2012 to 2025
$5.9M
NMR Fingerprinting: Leveraging optimal control pulse design, tailored isotope labeling, and machine learning to study intractable proteinsR01GM136859 · NIGMS · DANA-FARBER CANCER INST · PI ARTHANARI, HARIBABU · 2020 to 2024
$2.4M
Targeting protein-protein interactions as drug targetsR21AI156484 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2021 to 2022
$434k
NCRR NIH HHS P20 RR016454NIAID NIH HHS R21 AI156484NIGMS NIH HHS P20 GM103408NIGMS NIH HHS R01 GM095970NIGMS NIH HHS R01 GM136859
6 · The paper itself

Abstract

Acyl-homoserine lactone synthases make specific AHL quorum sensing signals to aid virulence in Gram-negative bacteria. Here, we use solution NMR spectroscopy to demonstrate that the carrier protein-enzyme interface accurately reveals substrate recognition mechanisms in two quorum signal synthases.

Indexed as

Bacterial ProteinsCarrier ProteinsAcyl-ButyrolactonesGram-Negative BacteriaQuorum SensingVirulenceAcyl-ButyrolactonesBacterial ProteinsCarrier Proteins

Identifiers

PMID36645064
PMCPMC9931420
OpenAlexW4312858718

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.