Evidence map›Paper›PMID 36645036›Full record

ArticleActa psychiatrica Scandinavica2023

Childhood trauma and depressive symptoms in bipolar disorder: A network analysis.

Anna L Wrobel, Sue M Cotton, Anuradhi Jayasinghe, Claudia Diaz-Byrd, Anastasia K Yocum, Alyna Turner, Olivia M Dean, Samantha E Russell, Elizabeth R Duval, Tobin J Ehrlich and 3 more

Abstract read
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In one paragraph

Article in Acta psychiatrica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna L WrobelIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-1864-0394
Sue M CottonOrygen, Parkville, Victoria, Australia.
Anuradhi JayasingheOrygen, Parkville, Victoria, Australia.
Claudia Diaz-ByrdDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Anastasia K YocumDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Alyna TurnerIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Olivia M DeanIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Samantha E RussellIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Elizabeth R DuvalDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Tobin J EhrlichDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-8066-2044
David F MarshallDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Michael BerkIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-5554-6946
Melvin G McInnisDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Funding

Neural Mechanisms Involved in Contextual Processing in PTSDK23MH109762 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUVAL, ELIZABETH · 2017 to 2021
$759k
NIMH NIH HHS K23 MH109762
6 · The paper itself

Abstract

backgroundChildhood trauma is related to an increased number of depressive episodes and more severe depressive symptoms in bipolar disorder. The evaluation of the networks of depressive symptoms-or the patterns of relationships between individual symptoms-among people with bipolar disorder with and without a history of childhood trauma may assist in further clarifying this complex relationship.

methodsData from over 500 participants from the Heinz C. Prechter Longitudinal Study of Bipolar Disorder were used to construct a series of regularised Gaussian Graphical Models. The networks of individual depressive symptoms-self-reported (Patient Health Questionnaire-9; n = 543) and clinician-rated (Hamilton Depression Rating Scale-17; n = 529)-among participants with bipolar disorder with and without a history of childhood trauma (Childhood Trauma Questionnaire) were characterised and compared.

resultsAcross the sets of networks, depressed mood consistently emerged as a central symptom (as indicated by strength centrality and expected influence); regardless of participants' history of childhood trauma. Additionally, feelings of worthlessness emerged as a key symptom in the network of self-reported depressive symptoms among participants with-but not without-a history of childhood trauma.

conclusionThe present analyses-although exploratory-provide nuanced insights into the impact of childhood trauma on the presentation of depressive symptoms in bipolar disorder, which have the potential to aid detection and inform targeted intervention development.

Indexed as

Adverse Childhood ExperiencesBipolar DisorderDepressionHumansLongitudinal StudiesSurveys and Questionnairesbipolar disorderchildhood abusedepressionmental disorderspsychiatry

Identifiers

PMID36645036
PMCPMC10953422

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.