Evidence map›Paper›PMID 36645005›Full record

ReviewBiochemical Society transactions2023

Use of invertebrates to model chemically induced parkinsonism-symptoms.

Clynton Lourenço Correa, Carlos Augusto Borges de Andrade Gomes, Andressa de Abreu Mello, Nathany da Silva Nogueira, Taiane Barreto Medeiros, Cintia Monteiro de Barros, Silvana Allodi

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemical Society transactions, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Clynton Lourenço CorreaFaculdade de Fisioterapia, Universidade Federal do Rio de Janeiro. R. Rodolpho Paulo Rocco 255 - HUCFF, Ilha do Fundão, Rio de Janeiro, RJ 21941-590, Brazil.
Carlos Augusto Borges de Andrade GomesPrograma de Pós-Graduação em Ciências Biológicas - Biofísica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
Andressa de Abreu MelloPrograma de Pós-Graduação em Ciências Biológicas - Biofísica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
Nathany da Silva NogueiraPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas - Instituto de Biodiversidade e Sustentabilidade Nupem, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Macaé, RJ 27965-045, Brazil.
Taiane Barreto MedeirosPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas - Instituto de Biodiversidade e Sustentabilidade Nupem, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Macaé, RJ 27965-045, Brazil.
Cintia Monteiro de BarrosPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas - Instituto de Biodiversidade e Sustentabilidade Nupem, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Macaé, RJ 27965-045, Brazil.
Silvana AllodiPrograma de Pós-Graduação em Ciências Biológicas - Biofísica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.ORCID 0000-0002-3053-3866
Universidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of neurological diseases is currently growing due to the combination of several factor, including poor lifestyle and environmental imbalance which enhance the contribution of genetic factors. Parkinson's disease (PD), a chronic and progressive neurological condition, is one of the most prevalent neurodegenerative human diseases. Development of models may help to understand its pathophysiology. This review focuses on studies using invertebrate models to investigate certain chemicals that generate parkinsonian-like symptoms models. Additionally, we report some preliminary results of our own research on a crustacean (the crab Ucides cordatus) and a solitary ascidian (Styela plicata), used after induction of parkinsonism with 6-hydroxydopamine and the pesticide rotenone, respectively. We also discuss the advantages, limits, and drawbacks of using invertebrate models to study PD. We suggest prospects and directions for future investigations of PD, based on invertebrate models.

Indexed as

Parkinson DiseaseParkinsonian DisordersAnimalsDisease Models, AnimalHumansInvertebratesRotenoneRotenoneanimal modelexperimental Parkinson's diseaseinvertebratestoxicology

Identifiers

PMID36645005
PMCPMC9987996
OpenAlexW4316467341

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.