Evidence map›Paper›PMID 36644879›Full record

ArticleCell transplantation

CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune Response.

Lu Cao, Xiaoqian Ma, Juan Zhang, Min Yang, Zhenhu He, Cejun Yang, Sang Li, Pengfei Rong, Wei Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Decoding TNF receptor superfamily control of CD4Cell communication and signaling : CCS · 2026
    Review
  2. CD25Frontiers in immunology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lu CaoThe Institute for Cell Transplantation and Gene Therapy, The Third XiangYa Hospital, Central South University, Changsha, China.ORCID 0000-0002-3602-0340
Xiaoqian MaThe Institute for Cell Transplantation and Gene Therapy, The Third XiangYa Hospital, Central South University, Changsha, China.ORCID 0000-0002-8315-9927
Juan ZhangThe Institute for Cell Transplantation and Gene Therapy, The Third XiangYa Hospital, Central South University, Changsha, China.
Min YangThe Institute for Cell Transplantation and Gene Therapy, The Third XiangYa Hospital, Central South University, Changsha, China.
Zhenhu HeDepartment of Radiology, The Third XiangYa Hospital, Central South University, Changsha, China.
Cejun YangThe Institute for Cell Transplantation and Gene Therapy, The Third XiangYa Hospital, Central South University, Changsha, China.
Sang LiThe Institute for Cell Transplantation and Gene Therapy, The Third XiangYa Hospital, Central South University, Changsha, China.
Pengfei RongDepartment of Radiology, The Third XiangYa Hospital, Central South University, Changsha, China.
Wei WangThe Institute for Cell Transplantation and Gene Therapy, The Third XiangYa Hospital, Central South University, Changsha, China.ORCID 0000-0002-3409-7846
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinically, xenotransplantation often leads to T-cell-mediated graft rejection. Immunosuppressive agents including polyclonal regulatory T cells (poly-Tregs) promote global immunosuppression, resulting in serious infections and malignancies in patients. Xenoantigen-expanded Tregs (xeno-Tregs) have become a promising immune therapy strategy to protect xenografts with fewer side effects. In this study, we aimed to identify an efficient and stable subset of xeno-Tregs. We enriched CD27

Indexed as

Interleukin-17T-Lymphocytes, RegulatoryTransplantation, HeterologousAnimalsAntigens, HeterophileCTLA-4 AntigenForkhead Transcription FactorsHumansLymphocyte ActivationMiceSTAT5 Transcription FactorSwineAntigens, HeterophileCTLA-4 AntigenForkhead Transcription FactorsInterleukin-17STAT5 Transcription Factorantigen-specific TregCD27immunosuppressioninflammationregulatory T cellsxenotransplantation

Identifiers

PMID36644879
PMCPMC9846302
OpenAlexW4316466425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.