ReviewIntegrative medicine (Encinitas, Calif.)2022
Distinctive Detoxification: The Case for Including the Microbiome in Detox Strategy.
Review in Integrative medicine (Encinitas, Calif.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Ecological and functional roles of plant microbiomes in environmental detoxification.Frontiers in microbiology · 2026Review
- Cross-platform assessment of short-form video quality on the gut-liver axis: informational integrity and engagement disparity.Frontiers in cellular and infection microbiology · 2025Article
- Activity of BiocidinFrontiers in antibiotics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to environmental toxins contributes to both acute and chronic illnesses, and is of growing concern. The importance of the microbiome to gastrointestinal (GI), as well as systemic health, has been the topic of much research recently. The microbiome influences health, and can either be a source of beneficial metabolites, or contribute to poor health. Dysbiosis, particularly in the GI tract, or oral cavity is a source of endogenously produced toxicity in the form of proinflammatory mediators-most notably lipopolysaccharide (LPS). LPS is cleared by the liver from enterohepatic circulation, and contributes to its workload. Bacterial overgrowth has been shown to be a contributing factor to liver disease. Further influences of the microbiome on detoxification include the Gut-Liver axis and biofilm production. Botanicals can have beneficial effects on microbial balance, favoring probiotic abundance, while addressing pathogen load. Additionally, plants offer antioxidant, biofilm disruption, antiinflammatory and immunomodulatory activities. Inclusion of botanical medicine to modulate the microbiome is a novel therapeutic target to reduce endogenously produced toxins and total toxic load.
Identifiers
36644597PMC9542931W4316687602What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.