Evidence map›Paper›PMID 36644236›Full record

ArticleJHEP reports : innovation in hepatology2023

Social support and risk of mortality in cirrhosis: A cohort study.

Gro Askgaard, Lone Galmstrup Madsen, Natasja von Wowern, Matilde Winther-Jensen, Cathrine Juel Lau, Anne Illemann Christensen, Colin Crooks, Joe West, Peter Jepsen

Open access · goldAbstract read
In one paragraph

Article in JHEP reports : innovation in hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Nurse-Led Clinic for Patients With Decompensated Liver Cirrhosis.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Clinical Ethics Consultations in Cirrhosis Care.Digestive diseases and sciences · 2025
    Article
  9. Article
  10. Article
  11. Multidimensional experience of pain in adults with cirrhosis: A qualitative descriptive study.Canadian journal of pain = Revue canadienne de la douleur · 2025
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Gro AskgaardDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Lone Galmstrup MadsenSection of Gastroenterology and Hepatology, Medical Department, Zealand University Hospital, Køge, Denmark.
Natasja von WowernSection of Gastroenterology and Hepatology, Medical Department, Zealand University Hospital, Køge, Denmark.
Matilde Winther-JensenCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, The Capital Region, Denmark.
Cathrine Juel LauCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, The Capital Region, Denmark.
Anne Illemann ChristensenNational Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Colin CrooksTranslational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
Joe WestTranslational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
Peter JepsenDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Frederiksberg Hospital · DKAarhus University · DKAarhus University Hospital · DKNottingham University Hospitals NHS Trust · GBUniversity of Nottingham · GBUniversity of Southern Denmark · DKZealand University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & Aims: The function and structure of social relationships influence mortality in individuals within the general population. We compared aspects of social relationships in individuals with cirrhosis and a matched comparison cohort and studied their association with health-related quality of life (HRQoL) and mortality in cirrhosis. Methods: Individuals with cirrhosis and comparators were identified among participants of the Danish National Health Surveys 2010-2017. The surveys included questions on functional (social support and loneliness) and structural (living alone/cohabitating and frequency of contacts with relatives and friends) aspects of social relationships and HRQoL (Short Form-12). We estimated associations of aspects of social relationships with HRQoL and all-cause mortality in individuals with cirrhosis through 2020. Results: Of 541 individuals with cirrhosis and 2,157 comparators, low social support (22% in cirrhosis Conclusions: Individuals with cirrhosis have weaker functional and structural social relationships than matched comparators. Weak functional relationships are associated with lower mental HRQoL and increased risk of mortality in individuals with cirrhosis. Impact and implications: This study investigated the prevalence of weak social relationships in individuals with cirrhosis and their influence on health-related quality of life and risk of mortality. Individuals with cirrhosis were nearly twice as likely to report low social support, loneliness, and to live alone than a matched comparison cohort. Low social support and loneliness (functional measures of social relationships) were associated with lower mental health-related quality of life and increased risk of mortality risk in cirrhosis, when adjusting for known confounders. We hope that these results will make healthcare providers aware of the functional aspects of the social relationships of individuals with cirrhosis, in addition to the traditional clinical management, and motivate further research of interventions to strengthen the social support of individuals with cirrhosis.

Indexed as

Alcohol-related liver diseaseCCI, Charlson Comorbidity IndexCirrhosisCohort studyDNHS, Danish National Health SurveysHR, Hazard RatioHRQoL, Health-Related Quality of LifeICD-10, International Classification of Diseases, Tenth RevisionISCED, International Standard Classification of EducationMortalitySF-12, Short Form-12Social relationshipsSocial support

Identifiers

PMID36644236
PMCPMC9832279
OpenAlexW4300861944

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.