Evidence map›Paper›PMID 36644127›Full record

ArticleAging pathobiology and therapeutics2022

Is aging "normal"?

Chloe Johnson, Warren Ladiges

Abstract read
In one paragraph

Article in Aging pathobiology and therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chloe JohnsonDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA.
Warren LadigesDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA.

Funding

Physical resilience is a predictor of healthy aging in miceR01AG057381 · NIA · UNIVERSITY OF WASHINGTON · PI Warren C LADIGES · 2017 to 2026
$4.6M
A geroscience approach for treating Alzheimer's diseaseR01AG067193 · NIA · UNIVERSITY OF WASHINGTON · PI DARVAS, MARTIN C, LADIGES, WARREN C · 2020 to 2024
$4.4M
NIA NIH HHS R01 AG057381NIA NIH HHS R01 AG067193
6 · The paper itself

Abstract

The descriptive term "normal" aging is often used in scientific literature to indicate commonly occurring changes with increasing age in the absence of overt disease. However, significant molecular and geropathological changes are increasingly present to indicate there is nothing normal about aging. Thus, the term "normal" aging is scientifically incorrect. There are changes in multiple genetic and epigenetic processes and pathways that drive aging, and some individuals are more resilient to these changes than others. Thus, "resilient" aging would be a more correct term to represent a major emphasis on investigating mechanisms and therapeutic targets for resilience, rather than a label of "normal" aging that is misleading and currently receives relatively little attention.

Indexed as

age-related changesAginggeropathology“Normal” agingresilient aging

Identifiers

PMID36644127
PMCPMC9836033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.