Evidence map›Paper›PMID 36643895›Full record

ArticleFASEB bioAdvances2023

Early developmental phenotypes in the cystic fibrosis sheep model.

Arnaud J Van Wettere, Shih-Hsing Leir, Calvin U Cotton, Misha Regouski, Iuri Viotti Perisse, Jenny L Kerschner, Alekh Paranjapye, Zhiqiang Fan, Ying Liu, Makayla Schacht and 3 more

Open access · goldAbstract read
In one paragraph

Article in FASEB bioAdvances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Cellular imbalance in proximal and distal lung of CFTRMolecular medicine (Cambridge, Mass.) · 2025
    Article
  5. Article
  6. Acquired dysfunction of CFTR underlies cystic fibrosis-like disease of the canine gallbladder.American journal of physiology. Gastrointestinal and liver physiology · 2024
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Arnaud J Van WettereDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.ORCID https://orcid.org/0000-0002-9611-1316
Shih-Hsing LeirDepartment of Genetics and Genome Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA.ORCID https://orcid.org/0000-0001-9524-3379
Calvin U CottonDepartments of Pediatrics, Physiology and Biophysics Case Western Reserve University School of Medicine Cleveland Ohio USA.
Misha RegouskiDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Iuri Viotti PerisseDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Jenny L KerschnerDepartment of Genetics and Genome Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA.
Alekh ParanjapyeDepartment of Genetics and Genome Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA.
Zhiqiang FanDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Ying LiuDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Makayla SchachtDepartment of Genetics and Genome Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA.
Kenneth L WhiteDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Irina A PolejaevaDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.ORCID https://orcid.org/0000-0002-0858-5889
Ann HarrisDepartment of Genetics and Genome Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA.ORCID https://orcid.org/0000-0002-6541-2546
Utah State University · USUniversity School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Highly effective modulator therapies for cystic fibrosis (CF) make it a treatable condition for many people. However, although CF respiratory illness occurs after birth, other organ systems particularly in the digestive tract are damaged before birth. We use an ovine model of CF to investigate the in utero origins of CF disease since the sheep closely mirrors critical aspects of human development. Wildtype (WT) and

Indexed as

CF developmentCF GI tractCF liverCF lungCF pancreasCF sheep modelCFTRCF tracheaearly CF pathology

Identifiers

PMID36643895
PMCPMC9832529
OpenAlexW4306657420

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.