ArticleCancer research communications2022
Expanding the prostate cancer cell line repertoire with ACRJ-PC28, an AR-negative neuroendocrine cell line derived from an African-Caribbean patient.
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Article in Cancer research communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
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Who cites it
12 citing papers in PubMed, 11 citations in OpenAlex.
- Advances in 3D culture systems for maintaining prostate tissue architecture and functional ex vivo prostate organ culture for biomedical applications.Molecular biology reports · 2026Review
- Establishing the first Afro-Caribbean breast cancer cell lines reveals ECM pathway enrichment and distinctive drug sensitivities.Scientific reports · 2026Article
- Integrative molecular analyses of lineage identity and morphology in aggressive variant prostate cancer.NPJ precision oncology · 2026Article
- PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration-resistant prostate cancer.Molecular oncology · 2026Article
- Molecular decoupling of lineage identity and morphology in aggressive variant prostate cancer.medRxiv : the preprint server for health sciences · 2026Article
- Novel Afro-Caribbean Prostate Cancer Model Reveals Ancestry-Specific Drug Vulnerabilities with Therapeutic Implications for Black Patients.Cancer research communications · 2025Article
- Chemopreventive Potential of Paddy Waste: A Promising Approach Against Benign Prostate Hyperplasia in Spontaneously Hypertensive Rats.Analytical cellular pathology (Amsterdam) · 2025Article
- Addressing health disparities and equitable representation in cancer research through the initiative, 'The Patient and Public Involvement Cancer Research Group for Diverse Backgrounds'.Ecancermedicalscience · 2025Article
- Failure to progress: breast and prostate cancer cell lines in developing targeted therapies.Cancer metastasis reviews · 2024Review
- Derivation of human primary prostate epithelial cell lines by differentially targeting the CDKN2A locus along with expression of hTERT.Scientific reports · 2024Article
- PARP-ish: Gaps in Molecular Understanding and Clinical Trials Targeting PARP Exacerbate Racial Disparities in Prostate Cancer.Cancer research · 2024Review
- Derivation of human primary prostate epithelial cell lines by differentially targeting theResearch square · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 5 institutions in 4 countries.
Henkel ValentineDepartment of Basic Medical Sciences, Faculty of Medical Sciences Teaching and Research Complex, The University of the West Indies, Mona, Jamaica, West Indies.
William AikenDepartment of Surgery, Radiology, Anaesthesia and Intensive Care, Section of Surgery, Faculty of Medical Sciences, The University of the West Indies, Mona, Jamaica.
Belinda MorrisonDepartment of Surgery, Radiology, Anaesthesia and Intensive Care, Section of Surgery, Faculty of Medical Sciences, The University of the West Indies, Mona, Jamaica.
Ziran ZhaoFels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine.
Holly FowleFels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine.
Jason S WassermanFels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine.
Elon ThompsonDepartment of Urology Kingston Public Hospital, North Street, Kingston.
Warren ChinDepartment of Urology Kingston Public Hospital, North Street, Kingston.
Mark YoungDepartment of Urology Kingston Public Hospital, North Street, Kingston.
Shannique ClarkeDepartment of Basic Medical Sciences, Faculty of Medical Sciences Teaching and Research Complex, The University of the West Indies, Mona, Jamaica, West Indies.
Denise GibbsCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Sharon HarrisonCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Wayne McLaughlinCARIGEN, Faculty of Medical Sciences Teaching and Research Complex, The University of the West Indies, Mona, Jamaica.
Tim KwokBlood Cell Development and Function Program and Cell Culture Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Fang JinBlood Cell Development and Function Program and Cell Culture Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Kerry S CampbellBlood Cell Development and Function Program and Cell Culture Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Anelia HorvathDepartment of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Rory ThompsonDepartment of Pathology, University Hospital of the West Indies, Mona.
Norman H LeeDepartment of Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, GW Cancer Center.
Yan ZhouBiostatistics and Bioinformatics Facility, Fox Chase Cancer Center.
Xavier GrañaFels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine.
Camille RaginAfrican Caribbean Cancer Consortium.
Simone BadalDepartment of Basic Medical Sciences, Faculty of Medical Sciences Teaching and Research Complex, The University of the West Indies, Mona, Jamaica, West Indies.
Fox Chase Cancer Center · USUniversity of the West Indies System · JMTemple University · USKingston Hospital · GBGeorge Washington University · US
Funding
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8MTUFCCC/HC Regional Comprehensive Cancer Health PartnershipU54CA221704 · NCI · HUNTER COLLEGE · PI Joel Erblich · 2018 to 2026
$10.6MConsequences and mechanism of aberrant splicing in African American prostate cancer disparitiesR01CA204806 · NCI · GEORGE WASHINGTON UNIVERSITY · PI GARCIA-BLANCO, MARIANO A., LEE, NORMAN H · 2017 to 2021
$1.8MUnraveling the complexity of substrate specificity of PP2A/B55a, a major eukaryote Serine/Threonine PhosphataseR01GM117437 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI GRANA, XAVIER · 2016 to 2019
$1.3MNovel Prostate Cancer Cell Lines to Address Prostate Cancer Disparity in Black MenK43TW011387 · FIC · UNIVERSITY OF THE WEST INDIES · PI BADAL, SIMONE ANNMARIE · 2020 to 2024
$586kThe coordination plan and community needs assessmentP20CA210294 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI TULLOCH-REID, MARSHALL KERR · 2017 to 2018
$548kPPP2R2A tumor suppression haploinsufficiency in prostate cancerR03CA216134 · NCI · TEMPLE UNIV OF THE COMMONWEALTH · PI GRANA, XAVIER · 2017 to 2018
$159kFIC NIH HHS K43 TW011387NCI NIH HHS P20 CA210294NCI NIH HHS P30 CA006927NCI NIH HHS R01 CA204806NCI NIH HHS R03 CA216134NCI NIH HHS U54 CA221704NIGMS NIH HHS R01 GM117437
Abstract
Prostate cell lines from diverse backgrounds are important to addressing disparities in prostate cancer (PCa) incidence and mortality rates among Black men. ACRJ-PC28 was developed from a transrectal needle biopsy and established via inactivation of the
Indexed as
Neuroendocrine CellsProstatic NeoplasmsCaribbean RegionCell LineHumansMaleRNA, MessengerTumor Suppressor Protein p53RNA, MessengerTumor Suppressor Protein p53BlackCaribbeanCell LinesProstate CancerProstate Cancer Cell Line
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.