ArticleAtherosclerosis plus2022
Identification of the atherosclerosis phenotype
Article in Atherosclerosis plus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Increased detectability of Apolipoprotein E (ApoE) in cerebrospinal fluid samples of dogs with peracute and acute central nervous system lesions.Frontiers in veterinary science · 2026Article
- Dog models of human atherosclerotic cardiovascular diseases.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims: This study evaluated the atherosclerosis phenotype by vascular duplex ultrasonography (VDU) in ApoE-deficient dogs. Methods: A total of 108 beagle dogs were examined by VDU, which included 32 wild-type, 68 heterozygous (ApoE-/+) mutant and 8 homozygous (ApoE-/-) mutant dogs. According to age, wild-type and ApoE-/+ dogs were divided into two subgroups: young (6-15 months) and adult dogs (18-29 months). All homozygous dogs were young dogs. Dogs were feed with normal diet. The plasma lipid levels were tested. The diameter of the common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA), abdominal aorta and common iliac artery (CIA) and the intima-media thickness (IMT) of the CCA and abdominal aorta were measured by VDU. The artery sections of ApoE-/- and control dogs were analyzed by histological analysis. Results: The plasma triglycerides (2.5-3 fold), total cholesterol (4-5 fold) and LDL levels (35-40 fold) of ApoE-/- dogs were higher than those of the wild-type and ApoE-/+ dogs. Compared with the wild-type and young ApoE-/+ dogs, the IMT of CCA and aorta in ApoE-/- dogs were increased ( Conclusions: The ApoE-deficient dogs were a reliable animal model of atherosclerosis. VDU is an optimal
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.