Evidence map›Paper›PMID 36643473›Full record

ArticleACS omega2023

Liposome-Encapsulated Melphalan Exhibits Potent Antimyeloma Activity and Reduced Toxicity.

Zhimei Lin, Bingyang Chu, Ying Qu, Xue Wei, Jingcao Huang, Fangfang Wang, Yu Feng, Xin Wang, Hongmei Luo, Xinyu Zhai and 6 more

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Zhimei LinDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Bingyang ChuState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan610041, P. R. China.
Ying QuDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Xue WeiDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Jingcao HuangDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Fangfang WangDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Yu FengDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Xin WangDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Hongmei LuoDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Xinyu ZhaiDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Juan XuDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Xiang LiuDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Li ZhangDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Fengjiao ChenDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Yu WuDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.
Yuhuan ZhengDepartment of Hematology, West China Hospital, Sichuan University, Chengdu610041, P. R. China.ORCID https://orcid.org/0000-0002-5855-4343
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple myeloma (MM), a plasma cell cancer in bone marrow, remains an incurable disease. Melphalan, an alkylating agent, is a conventional anticancer drug that is still widely used for MM treatment in clinics. However, melphalan-induced organ toxicity and side effects are common. In this study, we loaded melphalan into a liposomal capsule and constituted liposomal melphalan (liposomal MEL). Liposomal MEL particles were approximately 120 nm in size and stable

Identifiers

PMID36643473
PMCPMC9835516
OpenAlexW4313269096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.