ArticleACS omega2023
Influence of Enzymes on the In Vitro Degradation Behavior of Pure Zn in Simulated Gastric and Intestinal Fluids.
Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 14 citations in OpenAlex.
- Synergistic Alcalase-papain hydrolysis of egg white protein: enhancing structural unfolding, antioxidant activity, and gastrointestinal stability.Food chemistry: X · 2026Article
- Effect of niosome formation with chitosan coating on the stability and absorption of orally administered vesicular ursolic acid.Journal of materials science. Materials in medicine · 2026Article
- Metal-organic-framework-based sitagliptin-release platform for multieffective radiation-induced intestinal injury targeting therapy and intestinal flora protective capabilities.Journal of nanobiotechnology · 2024Article
- A detailed mechanism of degradation behaviour of biodegradable as-ECAPed Zn-0.8Mg-0.2Sr with emphasis on localized corrosion attack.Bioactive materials · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc (Zn) alloys are being developed as the degradable biomaterial. However, the corrosion mechanism of Zn in the gastrointestinal environment is seldom investigated and needs to be addressed. In this study, the impacts of enzymes on the degradation of pure Zn via electrochemical measurements and immersion were investigated. Pepsin and pancreatin affected the degradation of pure Zn. In contrast with the solutions without enzymes, the degradation rates declined with the addition of enzymes in solutions. However, localized corrosion was observed because the adsorption of pepsin was not a perfect barrier to prevent corrosion. The adsorbed pancreatin protected the samples from corrosion mainly at the initial stage of immersion. With immersion in the simulated intestinal fluid, adsorption and desorption of pancreatin occurred simultaneously on the sample surface. These findings allow the development of Zn alloy-implanted devices for the digestive tract as well as the understanding of the Zn corrosion mechanism in the gastrointestinal environment.
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Registered trials
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