Evidence map›Paper›PMID 36642994›Full record

ArticleCurrent opinion in biomedical engineering2023

Smart Orthopedic Biomaterials and Implants.

Jonathon T Intravaia, Trevon Graham, Hyun S Kim, Himansu S Nanda, Sangamesh G Kumbar, Syam P Nukavarapu

Open access · greenAbstract read
In one paragraph

Article in Current opinion in biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 36 citations in OpenAlex.

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  8. Engineering the Immune Response to Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jonathon T IntravaiaDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Trevon GrahamDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Hyun S KimDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Himansu S NandaTerasaki Institute, University of California, Los Angeles, CA, USA.
Sangamesh G KumbarDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Syam P NukavarapuDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
University of Connecticut · USUniversity of California, Los Angeles · US

Funding

Biodegradable Matrices for Bone HealingR01EB020640 · NIBIB · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUMBAR, SANGAMESH GURAPPA, YU, XIAOJUN · 2017 to 2020
$1.6M
Polysaccharide putty formulations for tissue regenerationR01EB034202 · NIBIB · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sangamesh Gurappa Kumbar · 2023 to 2026
$1.5M
Biodegradable Matrices with Structural and Physical Cues for Interface EngineeringR01EB030060 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI NUKAVARAPU, SYAM · 2020 to 2024
$1.4M
Supplement to Support the Acquisition of a High-Precision 3D PrinterR01NS134604 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sangamesh Gurappa Kumbar · 2024 to 2026
$1.3M
NIBIB NIH HHS R01 EB020640NIBIB NIH HHS R01 EB030060NIBIB NIH HHS R01 EB034202NINDS NIH HHS R01 NS134604
6 · The paper itself

Abstract

Musculoskeletal injuries including bone defects continue to present a significant challenge in orthopedic surgery due to suboptimal healing. Bone reconstruction strategies focused on the use of biological grafts and bone graft substitutes in the form of biomaterials-based 3D structures in fracture repair. Recent advances in biomaterials science and engineering have resulted in the creation of intricate 3D bone-mimicking structures that are mechanically stable, biodegradable, and bioactive to support bone regeneration. Current efforts are focused on improving the biomaterial and implant physicochemical properties to promote interactions with the host tissue and osteogenesis. The "smart" biomaterials and their 3D structures are designed to actively interact with stem/progenitor cells and the extracellular matrix (ECM) to influence the local environment towards osteogenesis and

Indexed as

bioactive implantsmagnetic and electric stimulipiezoelectricsmart biomaterialsstimuli-responsive

Identifiers

PMID36642994
PMCPMC9835562
OpenAlexW4313216057

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.