Evidence map›Paper›PMID 36642880›Full record

ArticleCurrent medicinal chemistry2023

Benefits of GLP-1 Mimetics on Epicardial Adiposity.

Habib Yaribeygi, Mina Maleki, Fatemeh Nasimi, Tannaz Jamialahmadi, Fatima C Stanford, Amirhossein Sahebkar

Open access · greenAbstract read
In one paragraph

Article in Current medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Habib YaribeygiResearch Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
Mina MalekiUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fatemeh NasimiResearch Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
Tannaz JamialahmadiSurgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Fatima C StanfordMassachusetts General Hospital, MGH Weight Center, Department of Medicine-Division of Endocrinology-Neuroendocrine, Department of Pediatrics-Division of Endocrinology, Nutrition Obesity Research Center at Harvard (NORCH), Harvard Medical School, Boston, MA, USA.
Amirhossein SahebkarApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Semnan University of Medical Sciences · IRBiotechnology Research Center · IRMashhad University of Medical Sciences · IRMassachusetts General Hospital · USShahid Beheshti University of Medical Sciences · IR

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Takara Leah Stanley · 1994 to 2026
$31.6M
Creating Opportunities for Unparalleled Researchers to Achieve Growth and Excellence (COURAGE)U24DK132733 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MORONE, NATALIA E., STANFORD, FATIMA CODY · 2022 to 2025
$3.3M
NIDDK NIH HHS P30 DK040561NIDDK NIH HHS U24 DK132733
6 · The paper itself

Abstract

The epicardial adipose tissue, which is referred to as fats surrounding the myocardium, is an active organ able to induce cardiovascular problems in pathophysiologic conditions through several pathways, such as inflammation, fibrosis, fat infiltration, and electrophysiologic problems. So, control of its volume and thickness, especially in patients with diabetes, is highly important. Incretin-based pharmacologic agents are newly developed antidiabetics that could provide further cardiovascular benefits through control and modulating epicardial adiposity. They can reduce cardiovascular risks by rapidly reducing epicardial adipose tissues, improving cardiac efficiency. We are at the first steps of a long way, but current evidence demonstrates the sum of possible mechanisms. In this study, we evaluate epicardial adiposity in physiologic and pathologic states and the impact of incretin-based drugs.

Indexed as

Diabetes Mellitus, Type 2Dipeptidyl-Peptidase IV InhibitorsAdiposityGlucagon-Like Peptide 1HumansHypoglycemic AgentsIncretinsObesityPericardiumDipeptidyl-Peptidase IV InhibitorsGlucagon-Like Peptide 1Hypoglycemic AgentsIncretinsDiabetes mellitusdipeptidyl peptidase-4 inhibitorepicardial adipose tissueepicardial adiposityglucagon-like peptide-1heart failure

Identifiers

PMID36642880
PMCPMC10293101
OpenAlexW4316362648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.