Evidence map›Paper›PMID 36642824›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2023

Wide-Field Three-Dimensional Depth-Invariant Cellular-Resolution Imaging of the Human Retina.

ByungKun Lee, Sunhong Jeong, Joosung Lee, Tae Shik Kim, Boy Braaf, Benjamin J Vakoc, Wang-Yuhl Oh

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Stretched-Pulse Mode-Locked Laser Using Post-Cavity Stretching for Ultrahigh-Speed OCT.IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society · 2025
    Article
  6. Frontiers in ophthalmology · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

ByungKun LeeDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.ORCID 0000-0001-8520-988X
Sunhong JeongDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
Joosung LeeDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
Tae Shik KimWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02140, USA.
Boy BraafWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02140, USA.
Benjamin J VakocWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02140, USA.ORCID 0000-0002-6623-3515
Wang-Yuhl OhDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.ORCID 0000-0002-7766-3086

Funding

TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Brett E Bouma · 2012 to 2026
$22.4M
NIBIB NIH HHS P41 EB015903
6 · The paper itself

Abstract

Three-dimensional (3D) cellular-resolution imaging of the living human retina over a large field of view will bring a great impact in clinical ophthalmology, potentially finding new biomarkers for early diagnosis and improving the pathophysiological understanding of ocular diseases. While hardware-based and computational adaptive optics (AO) optical coherence tomography (OCT) have been developed to achieve cellular-resolution retinal imaging, these approaches support limited 3D imaging fields, and their high cost and intrinsic hardware complexity limit their practical utility. Here, this work demonstrates 3D depth-invariant cellular-resolution imaging of the living human retina over a 3 × 3 mm field of view using the first intrinsically phase-stable multi-MHz retinal swept-source OCT and novel computational defocus and aberration correction methods. Single-acquisition imaging of photoreceptor cells, retinal nerve fiber layer, and retinal capillaries is presented across unprecedented imaging fields. By providing wide-field 3D cellular-resolution imaging in the human retina using a standard point-scan architecture routinely used in the clinic, this platform proposes a strategy for expanded utilization of high-resolution retinal imaging in both research and clinical settings.

Indexed as

RetinaTomography, Optical CoherenceBiomarkersHumansImaging, Three-DimensionalBiomarkerscellular-resolution retinal imagingcomputational imagingmulti-MHz phase-stable optical coherence tomography (OCT)optical coherence tomography

Identifiers

PMID36642824
PMCPMC10023497

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.