Evidence map›Paper›PMID 36642724›Full record

ArticleBMC public health2023

The burden of Parkinson's disease in the Middle East and North Africa region, 1990-2019: results from the global burden of disease study 2019.

Saeid Safiri, Maryam Noori, Seyed Aria Nejadghaderi, Seyed Ehsan Mousavi, Mark J M Sullman, Mostafa Araj-Khodaei, Kuljit Singh, Ali-Asghar Kolahi, Kurosh Gharagozli

Registry-linked trialAbstract read
In one paragraph

Article in BMC public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06612593 (The Effect of Cilostazol on the Clinical Outcome of Patients with Parkinson's Disease), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06612593 phase2not yet recruitingnot on this mapstarted 2024, after this paper: background citation

The Effect of Cilostazol on the Clinical Outcome of Patients with Parkinson's Disease

TypeinterventionalSponsorAin Shams UniversityRan2024 to 2025Enrolled50ConditionsParkinson's DiseaseArmsCilostazol, Placebo, Standard treatment
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
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  8. Article
  9. National and subnational burden of neurological disorders in Iran, 1990 to 2021: results from the global burden of disease study 2021.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
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  15. IntravenousJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
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  19. Article
  20. Burden of Parkinson's disease in Iran: disparities, trends, and the impact of social development indicators.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Saeid SafiriNeurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. safiris@tbzmed.ac.ir.
Maryam NooriStudent Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Seyed Aria NejadghaderiSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Ehsan MousaviStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Mark J M SullmanDepartment of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus.
Mostafa Araj-KhodaeiResearch Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Kuljit SinghDepartment of Medicine, Griffith University, Southport, QLD, Australia.
Ali-Asghar KolahiSocial Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Kurosh GharagozliBrain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. safiris@tbzmed.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParkinson's disease (PD) remains a common disabling progressive neurodegenerative disorder. We aimed to report the prevalence, death and disability-adjusted life-years (DALYs) attributable to PD in the Middle East and North Africa (MENA) region and its 21 countries by age, sex and socio-demographic index (SDI), between 1990 and 2019.

methodsPublicly available data on the burden of PD in the MENA countries were retrieved from the Global Burden of Disease (GBD) 2019 project. The results are presented with age-standardised numbers and rates per 100,000 population, along with their corresponding 95% uncertainty intervals (UIs).

resultsIn 2019, PD had an age-standardised point prevalence of 82.6 per 100,000 population in MENA and an age-standardised death rate of 5.3, which have increased from 1990 to 2019 by 15.4% and 2.3%, respectively. In 2019, the age-standardised DALY rate of PD was 84.4, which was 0.9% higher than in 1990. The highest and lowest age-standardised DALY rates of PD in 2019 were found in Qatar and Kuwait, respectively. Also in 2019, the highest number of prevalent cases and number of DALYs were found in the 75-79 age group for both sexes. In 2019, females in MENA had an overall higher DALY rate. Furthermore, from 1990 to 2019 the burden of PD generally decreased with increasing socio-economic development, up to an SDI of around 0.4, and then increased with higher levels of SDI.

conclusionAn upward trend was observed in the point prevalence of PD over the last three decades. This highlights the need to allocate more resources for research. Furthermore, properly equipped healthcare services are needed for the increasing number of patients with PD.

Indexed as

Global Burden of DiseaseParkinson DiseaseAfrica, NorthernFemaleGlobal HealthHumansIncidenceMaleMiddle EastPrevalenceQuality-Adjusted Life YearsRisk FactorsDisability-adjusted life-yearsEpidemiologyMiddle East and North AfricaMortalityParkinson’s disease

Identifiers

PMID36642724
PMCPMC9841703

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.