Evidence map›Paper›PMID 36642643›Full record

Trial reportAmerican journal of preventive medicine2023

Air Quality Index and Childhood Asthma: A Pilot Randomized Clinical Trial Intervention.

Franziska J Rosser, Scott D Rothenberger, Yueh-Ying Han, Erick Forno, Juan C Celedón

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of preventive medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04454125 (Air Quality Index), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04454125 nacompletednot on this map

Air Quality Index (AQI) and Childhood Asthma: an Intervention

TypeinterventionalSponsorUniversity of PittsburghRan2020 to 2021Enrolled40ConditionsAsthma, Asthma in ChildrenArmsAQI intervention, Routine care
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Interventions to reduce the impact of outdoor air pollution on asthma: A systematic review.African journal of thoracic and critical care medicine · 2024
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Franziska J RosserDivision of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: Franziska.rosser2@chp.edu.
Scott D RothenbergerDivision of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Yueh-Ying HanDivision of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.
Erick FornoDivision of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.
Juan C CeledónDivision of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Institutional Career Development CoreKL2TR001856 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, KRISTIN N, RUBIO, DORIS M · 2016 to 2025
$13.8M
Epigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8M
Nasal epithelial epigenomics and transcriptomics and asthma in Hispanic adultsR01HL152475 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS, ISASI, CARMEN R. · 2021 to 2025
$3.4M
Chronic outdoor air pollution, airway epithelial "omics" and asthma exacerbations in childrenK08HL159333 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSSER, FRANZISKA · 2021 to 2024
$641k
NCATS NIH HHS KL2 TR001856NCATS NIH HHS UL1 TR001857NHLBI NIH HHS K08 HL159333NHLBI NIH HHS R01 HL117191NHLBI NIH HHS R01 HL152475
6 · The paper itself

Abstract

introductionTo reduce air pollution exposure, the U.S. asthma guidelines recommend that children check the Air Quality Index before outdoor activity. Whether adding the Air Quality Index and recommendations to asthma action plans reduces exacerbations and improves control and quality of life in children with asthma is unknown.

methodsA pilot, unblinded, randomized clinical trial of 40 children with persistent asthma, stratified by age and randomized 1:1, recruited from the University of Pittsburgh Medical Center Children's Hospital of Pittsburgh (Pittsburgh, PA) was conducted. All participants received asthma action plans and Air Quality Index education. The intervention group received printed Air Quality Index information and showed the ability to use AirNow. Asthma exacerbations were assessed through a questionnaire, asthma control was assessed with the Asthma Control Test and Childhood Asthma Control Test, and quality of life was assessed with the Pediatric Asthma Quality of Life Questionnaire. After randomization (July-October 2020), participants were followed monthly for 6 months (exit January-March 2021). Outcome differences between groups were evaluated at the exit visit and over time (analysis was in 2021).

resultsAt randomization, there were no significant differences in age, sex, race, or asthma severity. At exit, more intervention participants checked the Air Quality Index (63% vs 15%) with no differences in the proportion of asthma exacerbations or mean Childhood Asthma Control Test or Pediatric Asthma Quality of Life Questionnaire scores. The mean change in Asthma Control Test score was higher in the intervention group (change in Asthma Control Test=2.00 vs 0.15 for the control), which was modified by time (β=1.85, CI=0.09, 3.61). Physical activity was decreased overall and showed modification by treatment and time.

conclusionsAddition of the Air Quality Index to asthma action plans led to improved asthma control by Asthma Control Test scores but may decrease outdoor activity.

Indexed as

Air PollutionAsthmaChildDisease ProgressionHumansPilot ProjectsQuality of Life

Identifiers

PMID36642643
PMCPMC10200724

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.