Evidence map›Paper›PMID 36642569›Full record

ReviewPathology2023

Diagnostic error, uncertainty, and overdiagnosis in melanoma.

David E Elder, Megan M Eguchi, Raymond L Barnhill, Kathleen F Kerr, Stevan R Knezevich, Michael W Piepkorn, Lisa M Reisch, Joann G Elmore

Open access · greenAbstract readReview
In one paragraph

Review in Pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Overdiagnosis of Melanoma In Situ.Journal of clinical medicine · 2026
    Review
  5. Article
  6. Melanoma Diagnosis in the Mihm Era-And Beyond.Journal of cutaneous pathology · 2026
    Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

David E ElderDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: elder@pennmedicine.upenn.edu.
Megan M EguchiDepartment of Medicine, University of California, David Geffen School of Medicine, Los Angeles, CA, USA.
Raymond L BarnhillDepartment of Translational Research, Institut Curie, and UFR of Medicine University of Paris, Paris, France.
Kathleen F KerrDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Stevan R KnezevichPathology Associates, Clovis, CA, USA; Division of Dermatology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Michael W PiepkornDivision of Dermatology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA; Dermatopathology Northwest, Bellevue, WA, USA.
Lisa M ReischDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Joann G ElmoreDepartment of Medicine, University of California, David Geffen School of Medicine, Los Angeles, CA, USA.
University of Washington · USUniversity of California, Los Angeles · USHospital of the University of Pennsylvania · USInstitut Curie · FR

Funding

Reducing Errors in the Diagnosis of Melanoma and Melanocytic LesionsR01CA201376 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G, KERR, KATHLEEN F. · 2016 to 2020
$3.2M
NCI NIH HHS R01 CA201376
6 · The paper itself

Abstract

Diagnostic error can be defined as deviation from a gold standard diagnosis, typically defined in terms of expert opinion, although sometimes in terms of unexpected events that might occur in follow-up (such as progression and death from disease). Although diagnostic error does exist for melanoma, deviations from gold standard diagnosis, certainly among appropriately trained and experienced practitioners, are likely to be the result of uncertainty and lack of specific criteria, and differences of opinion, rather than lack of diagnostic skills. In this review, the concept of diagnostic error will be considered in relation to diagnostic uncertainty, and the concept of overdiagnosis in melanoma will be presented and discussed.

Indexed as

MelanomaSkin NeoplasmsDiagnostic ErrorsHumansOverdiagnosisUncertaintydermatopathologydiagnostic uncertaintyMelanomaoverdiagnosisstandardised classification toolsurgical pathology

Identifiers

PMID36642569
PMCPMC10373372
OpenAlexW4313333097

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.