Evidence map›Paper›PMID 36642428›Full record

ArticleThe Journal of rheumatology2023

Comparative Effectiveness of BNT162b2 and mRNA-1273 Vaccines Against COVID-19 Infection Among Patients With Systemic Autoimmune Rheumatic Diseases on Immunomodulatory Medications.

Claire E Cook, Naomi J Patel, Xiaoqing Fu, Xiaosong Wang, Yumeko Kawano, Kathleen M M Vanni, Grace Qian, Emily Banasiak, Emily Kowalski, Hyon K Choi and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Observational
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Claire E CookC.E. Cook, MPH, X. Fu, MS, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, and Clinical Epidemiology Program, Mongan Institute, Department of Medicine, Massachusetts General Hospital.
Naomi J PatelN.J. Patel, MD, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, and Harvard Medical School.ORCID 0000-0002-6038-0346
Xiaoqing FuC.E. Cook, MPH, X. Fu, MS, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, and Clinical Epidemiology Program, Mongan Institute, Department of Medicine, Massachusetts General Hospital.
Xiaosong WangX. Wang, MS, K.M.M. Vanni, BA, G. Qian, BA&Sc, E. Banasiak, BA, E. Kowalski, BS, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Yumeko KawanoY. Kawano, MD, J.A. Sparks, MD, MMSc, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, and Harvard Medical School.
Kathleen M M VanniX. Wang, MS, K.M.M. Vanni, BA, G. Qian, BA&Sc, E. Banasiak, BA, E. Kowalski, BS, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Grace QianX. Wang, MS, K.M.M. Vanni, BA, G. Qian, BA&Sc, E. Banasiak, BA, E. Kowalski, BS, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Emily BanasiakX. Wang, MS, K.M.M. Vanni, BA, G. Qian, BA&Sc, E. Banasiak, BA, E. Kowalski, BS, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Emily KowalskiX. Wang, MS, K.M.M. Vanni, BA, G. Qian, BA&Sc, E. Banasiak, BA, E. Kowalski, BS, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Hyon K ChoiH.K. Choi, MD, DrPH, Y. Zhang, ScD, Z.S. Wallace, MD, MSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Clinical Epidemiology Program, Mongan Institute, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
Yuqing ZhangH.K. Choi, MD, DrPH, Y. Zhang, ScD, Z.S. Wallace, MD, MSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Clinical Epidemiology Program, Mongan Institute, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
Jeffrey A Sparks *Y. Kawano, MD, J.A. Sparks, MD, MMSc, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, and Harvard Medical School; zswallace@mgh.harvard.edu jsparks@bwh.harvard.edu.ORCID 0000-0002-5556-4618
Zachary S Wallace *H.K. Choi, MD, DrPH, Y. Zhang, ScD, Z.S. Wallace, MD, MSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Clinical Epidemiology Program, Mongan Institute, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA. zswallace@mgh.harvard.edu jsparks@bwh.harvard.edu.ORCID 0000-0003-4708-7038
Brigham and Women's Hospital · USMassachusetts General Hospital · USHarvard University · US

Funding

VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYticsP30AR072577 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel Hal Solomon · 2017 to 2026
$9.8M
Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung DiseaseR01AR077607 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SPARKS, JEFFREY ANDREW · 2021 to 2025
$3.7M
Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic DiseasesR01AR080659 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Jeffrey Andrew Sparks · 2023 to 2026
$2.9M
Impact of ANCA Type and Rituximab vs. Cyclophosphamide on Cardiovascular Risk, Mortality, and Quality-Adjusted Life Years inANCA-Associated VasculitisK23AR073334 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI WALLACE, ZACHARY SCOTT · 2018 to 2022
$948k
Personalizing AAV Management by Leveraging Big Data: Targeting Complication ClustersR03AR078938 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI WALLACE, ZACHARY SCOTT · 2021 to 2022
$189k
NIAMS NIH HHS K23 AR073334NIAMS NIH HHS P30 AR070253NIAMS NIH HHS P30 AR072577NIAMS NIH HHS R01 AR077607NIAMS NIH HHS R01 AR080659NIAMS NIH HHS R03 AR078938
6 · The paper itself

Abstract

objectiveTo compare the effectiveness of mRNA vaccines (BNT162b2 vs mRNA-1273) against coronavirus disease 2019 (COVID-19) infection among patients with systemic autoimmune rheumatic diseases (SARDs) on immunomodulatory medications.

methodsWe identified patients with SARDs being treated with disease-modifying antirheumatic drugs (DMARDs) and/or glucocorticoids in the Mass General Brigham healthcare system who received either BNT162b2 or mRNA-1273 as their initial vaccine series. Patients were followed until positive SARS-CoV-2 test, death, or February 22, 2022. We compared the risk of breakthrough infection between BNT162b2 and mRNA-1273 vaccine recipients using time-stratified, overlap propensity score (PS)-weighted Cox proportional hazard models.

resultsWe identified 9838 patients with SARDs who received BNT162b2 or mRNA-1273. Demographic and clinical characteristics were similar in both groups after overlap weighting: mean age 61 years, 75% female, 52% with rheumatoid arthritis, 74% receiving conventional synthetic DMARDs, and 43% receiving biologic DMARDs. Of 5516 BNT162b2 and 4322 mRNA-1273 recipients, 446 and 329 had a breakthrough infection, respectively. The corresponding time-stratified PS-weighted rate difference of breakthrough infection was 0.71 (95% CI -0.70 to 2.12) per 1000 person-months with a weighted hazard ratio (HR) of 1.12 (95% CI 0.90 to 1.39). When follow-up was censored prior to the Omicron wave, there was a trend toward higher breakthrough risk with BNT162b2 vs mRNA-1273 (weighted HR 1.34, 95% CI 0.91 to 1.98).

conclusionAmong patients with SARDs, the risk of breakthrough COVID-19 infection is similar after receiving either BNT162b2 or mRNA-1273. Patients with SARDs initiating the vaccine series should be encouraged to receive whichever mRNA vaccine is available.

Indexed as

Antirheumatic AgentsArthritis, RheumatoidCOVID-192019-nCoV Vaccine mRNA-1273BNT162 VaccineBreakthrough InfectionsCOVID-19 VaccinesFemaleHumansMaleMiddle AgedmRNA VaccinesSARS-CoV-22019-nCoV Vaccine mRNA-1273Antirheumatic AgentsBNT162 VaccineCOVID-19 VaccinesmRNA Vaccinesepidemiologyinfectionvaccines

Identifiers

PMID36642428
PMCPMC10416090
OpenAlexW4316254386

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.