Evidence map›Paper›PMID 36642108›Full record

Trial reportToxicology and applied pharmacology2023

Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts.

Monica L Vermillion Maier, Lisbeth K Siddens, Jamie M Pennington, Sandra L Uesugi, Susan C Tilton, Emily A Vertel, Kim A Anderson, Lane G Tidwell, Ted J Ognibene, Kenneth W Turteltaub and 2 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Toxicology and applied pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Monica L Vermillion MaierLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA; Department of Environmental and Molecular Toxicology, ALS 1007, Oregon State University, Corvallis, OR 97331, USA. Electronic address: monica.maier@oregonstate.edu.
Lisbeth K SiddensLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA. Electronic address: beth.siddens@oregonstate.edu.
Jamie M PenningtonLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA. Electronic address: jamie.pennington@oregonstate.edu.
Sandra L UesugiLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA. Electronic address: sandra.uesugi@oregonstate.edu.
Susan C TiltonDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA; NIEHS Superfund Research Program, Oregon State University, Corvallis, OR 97331, USA. Electronic address: susan.tilton@oregonstate.edu.
Emily A VertelLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA. Electronic address: vertele@oregonstate.edu.
Kim A AndersonDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA; NIEHS Superfund Research Program, Oregon State University, Corvallis, OR 97331, USA. Electronic address: kim.anderson@oregonstate.edu.
Lane G TidwellDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA. Electronic address: lane.tidwell@oregonstate.edu.
Ted J OgnibeneCenter for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA. Electronic address: ognibene1@llnl.gov.
Kenneth W TurteltaubCenter for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA; Biology and Biotechnology Research Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA. Electronic address: turteltaub2@llnl.gov.
Jordan N SmithNIEHS Superfund Research Program, Oregon State University, Corvallis, OR 97331, USA; Chemical Biology and Exposure Science, Pacific Northwest National Laboratory, Richland, WA 99354, USA. Electronic address: jordan.smith@pnnl.gov.
David E WilliamsLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA; NIEHS Superfund Research Program, Oregon State University, Corvallis, OR 97331, USA. Electronic address: david.williams@oregonstate.edu.

Funding

Research Experience and Training Coordination CoreP42ES016465 · NIEHS · OREGON STATE UNIVERSITY · PI Robyn L Tanguay · 2009 to 2026
$52.5M
MODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6M
Zebrafish Biomedical Research Facility CoreP30ES030287 · NIEHS · OREGON STATE UNIVERSITY · PI Molly L Kile · 2020 to 2026
$9.8M
National User Resource for Biological Accelerator Mass SpectrometryR24GM137748 · NIGMS · LAWRENCE LIVERMORE NATIONAL SECURITY, LLC · PI BENCH, GRAHAM · 2020 to 2024
$6.5M
Benzo[a]pyrene Micro-dosing of Humans: A New Tool for Exposure, Risk Assessment and PreventionR01ES028600 · NIEHS · OREGON STATE UNIVERSITY · PI WILLIAMS, DAVID E · 2018 to 2022
$2.5M
NIEHS NIH HHS P30 ES030287NIEHS NIH HHS P42 ES016465NIEHS NIH HHS R01 ES028600NIEHS NIH HHS T32 ES007060NIGMS NIH HHS R24 GM137748
6 · The paper itself

Abstract

Utilizing the atto-zeptomole sensitivity of UPLC-accelerator mass spectrometry (UPLC-AMS), we previously demonstrated significant first-pass metabolism following escalating (25-250 ng) oral micro-dosing in humans of [

Indexed as

Benzo(a)pyreneCarcinogensDietary SupplementsHumansIndolesToxicokinetics3,3'-diindolylmethaneBenzo(a)pyreneCarcinogensIndoles3,3’-diindolylmethaneAccelerator mass spectrometryBenzo[a]pyreneBrussels sproutsHuman carcinogen dosingToxicokinetics

Identifiers

PMID36642108
PMCPMC9946811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.