SynthesisMedicina oral, patologia oral y cirugia bucal2023
Pentoxifylline and tocopherol for the treatment of osteoradionecrosis of the jaws. A systematic review.
Synthesis in Medicina oral, patologia oral y cirugia bucal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Microenvironmental barriers to healing in osteoradionecrosis and opportunities for regenerative intervention.Bioactive materials · 2027Review
- Transoral Minimal Access Mandibular Reconstruction Using Fibula Free Flap in Osteoradionecrosis.The Laryngoscope · 2026Article
- ALT Rescue Flap With Iliac Crest Bone Graft and Spanning Plate for Mandibular ORN.The Laryngoscope · 2026Article
- Effects of CYP1A2 genetic polymorphisms on the pharmacokinetics of pentoxifylline and its active metabolites.BMC pharmacology & toxicology · 2026Article
- Radiation-Induced Fibrosis (RIF) in Head and Neck Squamous Cell Carcinoma (HNSCC): A Review.Cells · 2025Review
- From Mechanism to Therapy: The Role of MSC-EVs in Alleviating Radiation-Induced Injuries.Pharmaceutics · 2025Review
- One-Year Follow-Up of Non-Healing Socket in Hodgkin's Lymphoma Patient: Case Report and Literature Review on Management Strategies.Diagnostics (Basel, Switzerland) · 2025Article
- Pathological Fractures of the Mandible: Our Department's 15-Year Experience.Diagnostics (Basel, Switzerland) · 2025Article
- Managing Mandibular Osteoradionecrosis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Review
- Single-arm interventional versus observational studies for assessing efficacy: A meta-epidemiological study.Cochrane evidence synthesis and methods · 2025Article
- Interdisciplinary Collaboration in Head and Neck Cancer Care: Optimizing Oral Health Management for Patients Undergoing Radiation Therapy.Current oncology (Toronto, Ont.) · 2024Review
- Prophylactic Use of Pentoxifylline and Tocopherol for Prevention of Osteoradionecrosis of the Jaw after Dental Extraction in Post-Radiated Oral and Oropharyngeal Cancer Patients: An Initial Case Series.Dentistry journal · 2024Article
- Oral Surgery and Osteoradionecrosis in Patients Undergoing Head and Neck Radiation Therapy: An Update of the Current Literature.Biomedicines · 2023Review
- Oral Complications from Oropharyngeal Cancer Therapy.Cancers · 2023Review
- Purine Derivatives in the Management of Antiresorptive Drug-Related Osteonecrosis of the Jaw.Current health sciences journalArticle
- Non-Invasive Management of Osteoradionecrosis With Intra- and Extraoral Fistulas Using Combined Photodynamic and Photobiomodulation Therapy: A Case Report.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoradionecrosis of the jaws (ORNJ) is a severe and challenging complication of head and neck radiation therapy. Despite its aggressiveness and controversy respect to its efficacy, surgical intervention remains the main treatment modality. Nevertheless, due to advances in the understanding of ORNJ physiopathology, new treatment alternatives such as the combination of pentoxifylline with tocopherol (PENTO) have emerged. The aim of this systematic review was to assess the reported efficacy of PENTO for the treatment of ORNJ. Material and Methods: Studies were search using Pubmed, The Cochrane Library, Scopus, and Web of Science data bases following the PRISMA guidelines. Inclusion criteria were cohort, case series, randomized or non-randomized clinical studies published in English including human subjects who received PENTO as treatment for ORN of the jaws. Results: Eleven articles met the inclusion criteria and were included for data analysis. All studies reported patients with complete mucosal coverage with no exposed bone (considered healthy) after PENTO treatment, ranging from 16.6% to 100% of the patients, depending on the study. Clinical improvement or disease stabilization was reported between 7.6% and 66.6% of studied individuals, while disease progression was seen in only 5 studies involving 7.6 - 32% of patients.
conclusionsPENTO treatment achieved a complete disease control in a significant number of patients in all studies. However, there is no standardized protocol for administering the therapy. It is necessary to determine the pharmacological doses and to evaluate the benefits of adding antibiotics and clodronate. Good quality clinical trials are needed to develop a successful algorithm for the management of ORN of the jaws.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.