ArticleAnnals of neurology2023
Bradykinesia and Its Progression Are Related to Interhemispheric Beta Coherence.
Article in Annals of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- N2G calibrator: a cross-subject adversarial learning framework for neural signal-driven gait tracking in Parkinson's disease.Communications engineering · 2026Article
- Low-frequency activity in the subthalamic nucleus informs about the acute neuropsychiatric state in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Reduced pre-movement subthalamic beta desynchronization marks motor deficit in Parkinson's disease.Brain communications · 2026Article
- Effect of frequency on dual target deep brain stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Beyond beta rhythms: subthalamic aperiodic broadband power scales with Parkinson's disease severity-a cross-sectional multicentre study.EBioMedicine · 2025Article
- Deep oscillatory neural network.Scientific reports · 2025Article
- Closing the loop in DBS: A data-driven approach.Parkinsonism & related disorders · 2025Review
- Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease.Nature communications · 2025Article
- N2GNet tracks gait performance from subthalamic neural signals in Parkinson's disease.NPJ digital medicine · 2025Article
- Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy.NPJ Parkinson's disease · 2025Article
- Long-term efficacy of deep brain stimulation in Parkinson's disease: over 10-year follow-up and insights into the "DBS honeymoon".Therapeutic advances in neurological disorders · 2025Article
- N2GNet tracks gait performance from subthalamic neural signals in Parkinson's disease.Research square · 2024Article
- Asymmetries of the subthalamic activity in Parkinson's disease: phase-amplitude coupling among local field potentials.Brain communications · 2024Article
- Translating Pathological Brain Activity Primers in Parkinson's Disease Research.Research (Washington, D.C.) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveBradykinesia is the major cardinal motor sign of Parkinson disease (PD), but its neural underpinnings are unclear. The goal of this study was to examine whether changes in bradykinesia following long-term subthalamic nucleus (STN) deep brain stimulation (DBS) are linked to local STN beta (13-30 Hz) dynamics or a wider bilateral network dysfunction.
methodsTwenty-one individuals with PD implanted with sensing neurostimulators (Activa® PC + S, Medtronic, PLC) in the STN participated in a longitudinal 'washout' therapy study every three to 6 months for an average of 3 years. At each visit, participants were withdrawn from medication (12/24/48 hours) and had DBS turned off (>60 minutes) before completing a repetitive wrist-flexion extension task, a validated quantitative assessment of bradykinesia, while local field potentials were recorded. Local STN beta dynamics were investigated via beta power and burst duration, while interhemispheric beta synchrony was assessed with STN-STN beta coherence.
resultsHigher interhemispheric STN beta coherence, but not contralateral beta power or burst duration, was significantly associated with worse bradykinesia. Bradykinesia worsened off therapy over time. Interhemispheric STN-STN beta coherence also increased over time, whereas beta power and burst duration remained stable. The observed change in bradykinesia was related to the change in interhemispheric beta coherence, with greater increases in synchrony associated with further worsening of bradykinesia.
interpretationTogether, these findings implicate interhemispheric beta synchrony as a neural correlate of the progression of bradykinesia following chronic STN DBS. This could imply the existence of a pathological bilateral network contributing to bradykinesia in PD. ANN NEUROL 2023;93:1029-1039.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.