ArticleNeurobiology of aging2023
Adult lifespan maturation and degeneration patterns in gray and white matter: A mean apparent propagator (MAP) MRI study.
Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Article
- Lifespan normative modeling of brain microstructure.Nature communications · 2026Article
- Diffusion-relaxation MRI as virtual histology: separable microstructural signatures of AD pathology in ex vivo human brain.Research square · 2026Article
- Highly replicable multisite patterns of adolescent white matter maturation.bioRxiv : the preprint server for biology · 2026Article
- Separable multidimensional MRI signatures of cellular and structural pathology in Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.Human brain mapping · 2026Article
- Lifespan Normative Modeling of Brain Microstructure.bioRxiv : the preprint server for biology · 2025Article
- Complementary MR measures of white matter and their relation to cardiovascular health and cognition.Scientific reports · 2025Article
- Mapping the microstructure of human cerebral cortex in vivo with diffusion MRI.Communications biology · 2025Article
- Analysis of advanced diffusion models assessing white matter microstructure in Alzheimer's disease.Scientific reports · 2025Article
- Spatial transcriptomics of the aging mouse brain reveals origins of inflammation in the white matter.Nature communications · 2025Article
- High resolution diffusion tensor imaging of the human cortex reveals non-linear trajectories over the healthy lifespan.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neuronal microstructural changes in the human brain are associated with neurocognitive aging.Aging cell · 2024Article
- Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer's disease.Brain : a journal of neurology · 2024Article
- Neuronal microstructural changes in the human brain are associated with neurocognitive aging.bioRxiv : the preprint server for biology · 2024Article
- Feature attention graph neural network for estimating brain age and identifying important neural connections in mouse models of genetic risk for Alzheimer's disease.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Identification of diffusion, kurtosis, and propagator MRI markers of Alzheimer's disease pathology in post-mortem human tissue.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Direct segmentation of cortical cytoarchitectonic domains using ultra-high-resolution whole-brain diffusion MRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Associations of prior concussion severity with brain microstructure using mean apparent propagator magnetic resonance imaging.Human brain mapping · 2024Article
- Mapping the individual human cortex using multidimensional MRI and unsupervised learning.Brain communications · 2023Article
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5 authors.
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Abstract
The relationship between brain microstructure and aging has been the subject of intense study, with diffusion MRI perhaps the most effective modality for elucidating these associations. Here, we used the mean apparent propagator (MAP)-MRI framework, which is suitable to characterize complex microstructure, to investigate age-related cerebral differences in a cohort of cognitively unimpaired participants and compared the results to those derived using diffusion tensor imaging. We studied MAP-MRI metrics, among them the non-Gaussianity (NG) and propagator anisotropy (PA), and established an opposing pattern in white matter of higher NG alongside lower PA among older adults, likely indicative of axonal degradation. In gray matter, however, these two indices were consistent with one another, and exhibited regional pattern heterogeneity compared to other microstructural parameters, which could indicate fewer neuronal projections across cortical layers along with an increased glial concentration. In addition, we report regional variations in the magnitude of age-related microstructural differences consistent with the posterior-anterior shift in aging paradigm. These results encourage further investigations in cognitive impairments and neurodegeneration.
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