Evidence map›Paper›PMID 36641338›Full record

ArticleDental materials : official publication of the Academy of Dental Materials2023

Dentin primer based on a highly functionalized gelatin-methacryloyl hydrogel.

Ala Alia, Feng Gao, John C Mitchell, Joshua Gasiorowski, Mae Ciancio, Bhimanna Kuppast, Carmem Pfeifer, Marcela R Carrilho

Abstract read
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In one paragraph

Article in Dental materials : official publication of the Academy of Dental Materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ala AliaMidwestern University, College of Graduate Studies, Biomedical Sciences Program, Downers Grove, IL, USA; Midwestern University, College of Dental Medicine-Illinois, Downers Grove, IL, USA.
Feng GaoMidwestern University, College of Dental Medicine-Illinois, Downers Grove, IL, USA.
John C MitchellMidwestern University, College of Dental Medicine-Illinois, Downers Grove, IL, USA; Midwestern University, College of Dental Medicine-Arizona, Glendale, IL, USA.
Joshua GasiorowskiMidwestern University, College of Graduate Studies, Biomedical Sciences Program, Downers Grove, IL, USA.
Mae CiancioMidwestern University, College of Graduate Studies, Biomedical Sciences Program, Downers Grove, IL, USA.
Bhimanna KuppastMidwestern University, Chicago College of Pharmacy, Pharmaceutical Sciences, Downers Grove, IL, USA.
Carmem PfeiferOregon Health & Science University, School of Dentistry, Biomaterials and Biomechanics, Portland, OR, USA.
Marcela R CarrilhoMidwestern University, College of Dental Medicine-Illinois, Downers Grove, IL, USA. Electronic address: mcarri@midwestern.edu.

Funding

Blending Dentin to Dentin: Biometric Hydrogels for Dentin Tissue EngineeringR15DE032836 · NIDCR · MIDWESTERN UNIVERSITY · PI ROCHA DE OLIVEIRA CARRILHO, MARCELA · 2023 to 2023
$422k
NIDCR NIH HHS R15 DE032836
6 · The paper itself

Abstract

Gelatin-methacryloyl hydrogels (GelMA) have demonstrated their utility as scaffolds in a variety of tissue engineering applications.

objectivesIn this study, a highly functionalized GelMA hydrogel was synthesized and assessed for degree of functionalization. As the proposed GelMA hydrogel was coupled to a visible-light photoinitiator, we hypothesized it might serve as base to formulate a model dentin primer for application in restorative dentistry.

methodsGelMA was mixed with photoinitiator lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP), photopolymerized for 0-40 s using a dental light-curing device and tested for extrudability, degree of photo-crosslinking (DPxlink), water sorption/solubility/swelling (WS/SL/SW) and apparent modulus of elasticity (AE). Model dentin primer was prepared by mixing GelMA+LAP with a primer of a commercial three-step etch-and-rinse adhesive. After application of GelMA-based primer to acid-etched dentin, samples were bonded with correspondent adhesive agent, photopolymerized and had their immediate bond strength compared to control samples primed and bonded with the same commercial material.

resultsExtrudability of hydrogel was confirmed using a microsyringe to write the acronym "CDMI". DPxlink of GelMA+LAP changed significantly as a function of photopolymerization time (20 s < 30 s ≤ 40 s). WS, SL and SW were significantly reduced in hydrogels polymerized for 30 and 40 s. AE of hydrogels varied significantly as a function of photopolymerization time (20 s < 30 s ≤ 40 s; 20 s ‡ 40 s). Bond strength of dentin primed with GelMA-based primer was lower (∼29.3 MPa) but not significantly of that of control (∼34.6 MPa).

conclusionsOptimization of a GelMA-based dentin primers can lead to the development of promising biomimetic adhesives for dentin rehabilitation.

Indexed as

GelatinHydrogelsDental CementsDentinMethacrylatesTissue EngineeringDental CementsGelatinHydrogelsMethacrylatesDentinExtracellular matrixGelatinHydrogelsMethacrylamidesModel bonding agents

Identifiers

PMID36641338
PMCPMC11391902

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.