ArticleNeuron2023
Humidity sensors that alert mosquitoes to nearby hosts and egg-laying sites.
Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Behavioral determinants of disease transmission by mosquitoes.Current opinion in insect science · 2026Review
- Undernutrition enhances host attractiveness to mosquitoes and transmission of mosquito-borne diseases.Cell research · 2026Article
- The HOST assay: an automated video-based evaluation of mosquito attraction to thermal infrared.Nature protocols · 2026Review
- Recurrent synapses between CO2-sensitive olfactory sensory neurons enable robust CO2 detection in Aedes aegypti mosquitoes.PLoS biology · 2026Article
- Article
- Odorant receptor coexpression and multi-expression in the dengue mosquito.Nature communications · 2026Article
- Mosquito heat and humidity detection in host seeking and oviposition behavior.Current opinion in neurobiology · 2026Review
- Advances in mosquito olfaction: Genetic, genomic, and behavioral approaches in Aedes aegypti.Current opinion in neurobiology · 2026Review
- The sensory biology of mosquito gustation.Current opinion in neurobiology · 2026Review
- Humidity as a potential zeitgeber for circadian entrainment of insect systems.Npj biological timing and sleep · 2026Article
- The role of tropical cyclones in accelerating dengue transmission: insights from field experiments and dynamical modelling.BMJ global health · 2026Article
- GravidInsects · 2026Article
- Interpopulation Variation in Egg Mortality in Response to Hot and Dry Conditions in North American Populations of the Invasive Tiger Mosquito,Ecology and evolution · 2026Article
- Functional characterization of AsOBP21f, an odorant-binding protein involved in human odor detection in the malaria vector Anopheles sinensis.Parasites & vectors · 2026Article
- Predicting mosquito flight behavior using Bayesian dynamical systems learning.Science advances · 2026Article
- Gustatory avoidance of fatty acids byProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- Environmental Factors That Regulate Mosquito Physiology and Behavior.Annual review of entomology · 2026Review
- Article
- Post-biting behavioral reprogramming underlies reproductive efficiency in Aedes aegypti mosquitoes.Cell reports · 2025Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
To reproduce and to transmit disease, female mosquitoes must obtain blood meals and locate appropriate sites for egg laying (oviposition). While distinct sensory cues drive each behavior, humidity contributes to both. Here, we identify the mosquito's humidity sensors (hygrosensors). Using generalizable approaches designed to simplify genetic analysis in non-traditional model organisms, we demonstrate that the ionotropic receptor Ir93a mediates mosquito hygrosensation as well as thermosensation. We further show that Ir93a-dependent sensors drive human host proximity detection and blood-feeding behavior, consistent with the overlapping short-range heat and humidity gradients these targets generate. After blood feeding, gravid females require Ir93a to seek high humidity associated with preferred egg-laying sites. Reliance on Ir93a-dependent sensors to promote blood feeding and locate potential oviposition sites is shared between the malaria vector Anopheles gambiae and arbovirus vector Aedes aegypti. These Ir93a-dependent systems represent potential targets for efforts to control these human disease vectors.
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