Evidence map›Paper›PMID 36640686›Full record

ArticleDrug and alcohol dependence2023

Associations between right inferior frontal gyrus morphometry and inhibitory control in individuals with nicotine dependence.

Alexander A Brown, Spencer Upton, Stephen Craig, Brett Froeliger

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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  8. Associations Between the Wisconsin Inventory of Smoking Dependence Motives and Regional Brain Volumes in Adult Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alexander A BrownDepartment of Psychiatry, University of Missouri, Columbia, MO, USA; Department of Psychological Sciences, University of Missouri, Columbia, MO, USA; Cognitive Neuroscience Systems Core Facility, University of Missouri, Columbia, MO, USA.
Spencer UptonDepartment of Psychological Sciences, University of Missouri, Columbia, MO, USA.
Stephen CraigDepartment of Psychiatry, University of Missouri, Columbia, MO, USA; Department of Psychological Sciences, University of Missouri, Columbia, MO, USA; Cognitive Neuroscience Systems Core Facility, University of Missouri, Columbia, MO, USA.
Brett FroeligerDepartment of Psychiatry, University of Missouri, Columbia, MO, USA; Department of Psychological Sciences, University of Missouri, Columbia, MO, USA; Cognitive Neuroscience Systems Core Facility, University of Missouri, Columbia, MO, USA. Electronic address: froeligerb@health.missouri.edu.
University of Missouri · USUniversity of Missouri Health System · US

Funding

Translational Neuropsychopharmacology Research of Nicotine AddictionR01DA038700 · NIDA · UNIVERSITY OF MISSOURI-COLUMBIA · PI FROELIGER, BRETT, GRAY, KEVIN M · 2015 to 2019
$2.9M
Neural mechanisms mediating appetitive regulation and smoking in nicotine addictionR01DA048094 · NIDA · UNIVERSITY OF MISSOURI-COLUMBIA · PI FROELIGER, BRETT, GARLAND, ERIC LEE · 2019 to 2023
$2.2M
Examining the effects of Theta Burst Stimulation on corticothalamic mediated inhibitory control and smoking relapse vulnerability.UG3DA048510 · NIDA · UNIVERSITY OF MISSOURI-COLUMBIA · PI FROELIGER, BRETT · 2019 to 2020
$734k
NIDA NIH HHS R01 DA038700NIDA NIH HHS R01 DA048094NIDA NIH HHS UG3 DA048510
6 · The paper itself

Abstract

backgroundThe hyperdirect pathway - a circuit involved in executing inhibitory control (IC) - is dysregulated among individuals with nicotine dependence. The right inferior frontal gyrus (rIFG), a cortical input to the hyperdirect circuit, has been shown to be functionally and structurally altered among nicotine-dependent people who smoke. The rIFG is composed of 3 cytoarchitecturally distinct subregions: The pars opercularis, pars triangularis, and pars orbitalis. The present study assessed the relationship between rIFG subregion morphometry and inhibitory control among individuals with nicotine dependence.

methodsBehavioral and magnetic resonance brain imaging (MRI) data from 127 nicotine-dependent adults who smoke (M RESULTS AND

conclusionsVertex-wise analyses revealed that GGNG task scores were positively associated with cortical thickness and volume in the right pars triangularis (cluster-wise p = 0.006, 90% CI = 0.003 - 0.009; cluster-wise p = 0.040, 90% CI = 0.032 - 0.048), and the ability to inhibit ad lib smoking during the SRT was positively associated with cortical thickness in the right pars orbitalis (cluster-wise p = 0.011, 90% CI = 0.007 - 0.015). Our results indicate that cortical thickness of distinct rIFG subregions may serve as biomarkers for unique forms of IC deficits.

Indexed as

NicotineTobacco Use DisorderAdultBrainHumansMagnetic Resonance ImagingPrefrontal CortexNicotineaddictioninhibitory controlmagnetic resonance imagingnicotinesmoking cessation

Identifiers

PMID36640686
PMCPMC9974751
OpenAlexW4313731366

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.