ArticleCell reports2023
Defining the age-dependent and tissue-specific circadian transcriptome in male mice.
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Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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106citing papers in PubMed
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Who cites it
106 citing papers in PubMed, 137 citations in OpenAlex.
- Stable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.Life metabolism · 2026Review
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- Aging in Spaceflight, Oxidative Stress, and Microbiome Dysbiosis: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis.Neuron · 2026Article
- Housing Mice in Thermoneutrality Causes Tissue-specific Changes in Number, Identity, and Phase of Circadian-expressed mRNA Transcripts.bioRxiv : the preprint server for biology · 2026Article
- mTOR signaling contributes to system-driven rhythmic gene expression in mouse liver.Science advances · 2026Article
- Chrono-Exercise Medicine: Why Biological Timing Matters for Human Health.Biomedicines · 2026Article
- Circadian regulation of cardiovascular function: from physiology to clinical implications.Genome medicine · 2026Review
- Circadian biology and exercise: the time to move.Life metabolism · 2026Review
- Aging-Related Muscle Bmal1 Decline Contributes to Bone Loss in Mice via Enhancing IL-1α-Mediated Osteoclastogenesis.Aging cell · 2026Article
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- Small-Molecule Modulation of the Circadian Clock in Cancer and Aging.Molecules (Basel, Switzerland) · 2026Review
- Redox rhythms promote fitness by modulating ageing-dependent reprogramming.Nature metabolism · 2026Article
- Time-Restricted Feeding Alters Behavior in a Sex-Specific Manner in Mice With Neuropathic Pain.Molecular nutrition & food research · 2026Article
- The Interplay Between Circadian Clocks and the Tumour Microenvironment in Breast Cancer.Cancers · 2026Review
- NADCommunications biology · 2026Article
46 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 2 institutions in 1 country.
Christopher A WolffDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Myology Institute, University of Florida, Gainesville, FL 32610, USA.
Miguel A Gutierrez-MonrealDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Myology Institute, University of Florida, Gainesville, FL 32610, USA; Claude D. Pepper Older Americans Independence Center, University of Florida, Gainesville, FL 32610, USA.
Lingsong MengDepartment of Biostatistics, University of Florida, Gainesville, FL 32610, USA.
Xiping ZhangDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Myology Institute, University of Florida, Gainesville, FL 32610, USA.
Lauren G DoumaDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA.
Hannah M CostelloDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA.
Collin M DouglasDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Myology Institute, University of Florida, Gainesville, FL 32610, USA.
Elnaz EbrahimiDepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Ann PhamDepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Aline C OliveiraDepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Chunhua FuDepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Amy NguyenDepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Bryan R AlavaDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Stuart J HeskethDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Myology Institute, University of Florida, Gainesville, FL 32610, USA.
Andrew R MorrisDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Mehari M EndaleDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
G Ryan CrislipDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Kit-Yan ChengDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Elizabeth A SchroderInternal Medicine, Pulmonary, University of Kentucky, Lexington, KY 40506, USA; Department of Physiology, University of Kentucky, Lexington, KY 40506, USA.
Brian P DelisleDepartment of Physiology, University of Kentucky, Lexington, KY 40506, USA.
Andrew J BryantDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA.
Michelle L GumzDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA; Center for Integrative Cardiovascular and Metabolic Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Zhiguang HuoDepartment of Biostatistics, University of Florida, Gainesville, FL 32610, USA. Electronic address: zhuo@ufl.edu.
Andrew C LiuDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address: andrew.liu@ufl.edu.
Karyn A EsserDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Myology Institute, University of Florida, Gainesville, FL 32610, USA; Claude D. Pepper Older Americans Independence Center, University of Florida, Gainesville, FL 32610, USA. Electronic address: kaesser@ufl.edu.
University of Florida · USUniversity of Kentucky · US
Funding
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8MMolecular, Cellular and Physiological Mechanisms of the Mammalian Circadian ClockR01NS054794 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HOGENESCH, JOHN B, LIU, ANDREW C. · 2007 to 2022
$8.1MTraining Program in Regenerative MedicineT32DK074367 · NIDDK · UNIVERSITY OF FLORIDA · PI SCOTT, EDWARD W · 2007 to 2022
$2.9MMuscle clock and weakness: diversity supplementR01AR079220 · NIAMS · UNIVERSITY OF FLORIDA · PI ESSER, KARYN A · 2021 to 2025
$2.8MCircadian clock regulation of myocardial ion channel expression and functionR01HL153042 · NHLBI · UNIVERSITY OF FLORIDA · PI DELISLE, BRIAN P, ESSER, KARYN A · 2020 to 2023
$2.6MTranscriptional Regulation of KCNH2R01HL141343 · NHLBI · UNIVERSITY OF KENTUCKY · PI DELISLE, BRIAN P · 2019 to 2022
$2.3MRole of ADAM17 in MDSC-Mediated Development of Pulmonary HypertensionR01HL142887 · NHLBI · UNIVERSITY OF FLORIDA · PI BRYANT, ANDREW JUSTIN · 2020 to 2024
$1.9MRole of CXCR2-mediated cell trafficking in pulmonary vascular remodelingR01HL142776 · NHLBI · UNIVERSITY OF FLORIDA · PI BRYANT, ANDREW JUSTIN · 2019 to 2023
$1.9MRole of mTOR in Circadian and Sleep Deregulation in Smith-Kingsmore Syndrome (SKS)R01NS117457 · NINDS · UNIVERSITY OF FLORIDA · PI Andrew C. Liu · 2023 to 2026
$1.8MPer1 and the kidney clock in hypertensionR01DK109570 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L · 2017 to 2021
$1.5MModulation of the renal aldosterone endothelin feedback system by the clock protein PER1R56DK128271 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L, WINGO, CHARLES S · 2021 to 2021
$100kNHLBI NIH HHS R01 HL141343NHLBI NIH HHS R01 HL142776NHLBI NIH HHS R01 HL142887NHLBI NIH HHS R01 HL153042NIAMS NIH HHS R01 AR079220NIA NIH HHS P30 AG028740NIDDK NIH HHS R01 DK109570NIDDK NIH HHS R56 DK128271NIDDK NIH HHS T32 DK074367NINDS NIH HHS R01 NS054794NINDS NIH HHS R01 NS117457
Abstract
Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated changes in circadian functions. To define age-dependent changes at the systems level, we profile the circadian transcriptome in the hypothalamus, lung, heart, kidney, skeletal muscle, and adrenal gland in three age groups. We find age-dependent and tissue-specific clock output changes. Aging reduces the number of rhythmically expressed genes (REGs), indicative of weakened circadian control. REGs are enriched for the hallmarks of aging, adding another dimension to our understanding of aging. Analyzing differential gene expression within a tissue at four different times of day identifies distinct clusters of differentially expressed genes (DEGs). Increased variability of gene expression across the day is a common feature of aged tissues. This analysis extends the landscape for understanding aging and highlights the impact of aging on circadian clock function and temporal changes in gene expression.
Indexed as
Circadian ClocksTranscriptomeAgingAnimalsCircadian RhythmHypothalamusMaleMiceadrenal glandagingcircadian clockCP: Developmental biologyCP: Molecular biologyhearthypothalamuskidneylungRNA-seqskeletal muscle
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