Evidence map›Paper›PMID 36640191›Full record

ArticleDiabetologia2023

Congenital malformations among offspring of women with type 1 diabetes who use insulin pumps: a prospective cohort study.

Ida H Thorius, Lise Lotte N Husemoen, Rikke B Nordsborg, Amra C Alibegovic, Mari-Anne Gall, Janne Petersen, Elisabeth R Mathiesen

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Diabetologia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ida H ThoriusCenter for Pregnant Women with Diabetes, Department of Endocrinology, Rigshospitalet, and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. idht@novonordisk.com.ORCID http://orcid.org/0000-0001-8506-457X
Lise Lotte N HusemoenNovo Nordisk A/S, Søborg, Denmark.
Rikke B NordsborgNovo Nordisk A/S, Søborg, Denmark.
Amra C AlibegovicNovo Nordisk A/S, Søborg, Denmark.
Mari-Anne GallNovo Nordisk A/S, Søborg, Denmark.
Janne PetersenCopenhagen Phase IV Unit, Department of Clinical Pharmacology and Center for Clinical Research and Prevention, Copenhagen University Hospital, Frederiksberg, Denmark.
Elisabeth R MathiesenCenter for Pregnant Women with Diabetes, Department of Endocrinology, Rigshospitalet, and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Novo Nordisk (Denmark) · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisContinuous subcutaneous insulin infusion by insulin pump is often superior in improving glycaemic control compared with conventional multiple daily insulin injection (MDI). However, whether pump treatment leads to improved pregnancy outcomes in terms of congenital malformations and perinatal death remains unknown. The present aim was to evaluate the risk of malformations and perinatal and neonatal death in pregnant women with type 1 diabetes treated with pump or MDI.

methodsWe performed a secondary analysis of a prospective multinational cohort of 2088 pregnant women with type 1 diabetes in a real-world setting who were treated by pump (n=750) or MDI (n=1338). ORs for offspring with congenital malformations or perinatal or neonatal death were calculated using crude data and by logistic regression on propensity score-matched data.

resultsAt enrolment (gestational week 8; 95% CI 4, 14), pump users had a higher educational level (university degree: 37.3% vs 25.1%; p<0.001) and better glycaemic control (mean HbA CONCLUSIONS/INTERPRETATIONS: Insulin pump treatment was not associated with a lower risk of congenital malformations, despite better glycaemic control in early pregnancy compared with MDI. Further studies exploring the efficacy and safety of pump treatment during pregnancy are needed.

Indexed as

Diabetes Mellitus, Type 1Perinatal DeathFemaleGlycated HemoglobinHumansHypoglycemic AgentsInfant, NewbornInjections, SubcutaneousInsulinInsulin Infusion SystemsPregnancyProspective StudiesGlycated HemoglobinHypoglycemic AgentsInsulinCongenital malformationsContinuous subcutaneous insulin infusion pump therapyPerinatal deathPregnancy outcomesType 1 diabetes mellitus

Identifiers

PMID36640191
OpenAlexW4316174631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.