Evidence map›Paper›PMID 36640190›Full record

ArticlePsychopharmacology2023

Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetine.

Daniel R Rosell, Mark Slifstein, Judy Thompson, Xiaoyan Xu, M Mercedes Perez-Rodriguez, Margaret M McClure, Erin A Hazlett, Antonia S New, Nabeel Nabulsi, Yiyun Huang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Daniel R RosellDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Mark SlifsteinDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, 11794, USA.
Judy ThompsonDepartment of Psychiatry, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Xiaoyan XuDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA.
M Mercedes Perez-RodriguezDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Margaret M McClureDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Erin A HazlettDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Antonia S NewDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Nabeel NabulsiDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Yiyun HuangDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Larry S SieverDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Anissa Abi-DarghamDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, 11794, USA.
Harold W KoenigsbergDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. harold.koenigsberg@mssm.edu.
Icahn School of Medicine at Mount Sinai · USYale University · USJames J. Peters VA Medical Center · USStony Brook University · USColumbia University · USUniversity of Rochester Medical Center · US

Funding

ZIPRASIDONE (GEODON) AUGMENTATION IN SEROTONIN REUPTAKE INHIBITOR-RESISTANT OBM01RR000071 · NCRR · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GOODMAN, MARC T · 1985 to 2009
$41.5M
Imaging 5-HTT &5-HT2a in Impulsive AggressionR01MH063875 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI KOENIGSBERG, HAROLD W · 2002 to 2012
$4.4M
Regulating Emotional Responses to Spoken Comments and Visual Images Across the Affective Instability Spectrum: An fMRI StudyR01MH109730 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOENIGSBERG, HAROLD W · 2016 to 2020
$3.1M
Neural, computational and behavioral characterization of dynamic social behavior in borderline and avoidant personality disorderR01MH123069 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GU, XIAOSI, KOENIGSBERG, HAROLD W · 2021 to 2025
$3.1M
Cognitive Reappraisal Training Targeting Emotion Circuits As a Therapeutic Intervention in Borderline PatientsR61MH125130 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOENIGSBERG, HAROLD W · 2021 to 2022
$1.9M
CSRD VA IK6 CX001738NCRR NIH HHS M01 RR000071NCRR NIH HHS MO1-RR-00071NIMH NIH HHS MH63875NIMH NIH HHS R01 MH063875NIMH NIH HHS R01 MH109730NIMH NIH HHS R01 MH123069NIMH NIH HHS R61 MH125130
6 · The paper itself

Abstract

rationaleCharacterizing the neuroanatomical basis of serotonergic abnormalities in severe, chronic, impulsive aggression will allow for rational treatment selection, development of novel therapeutics, and biomarkers to identify at-risk individuals.

objectivesThe aim of this study is to identify associations between regional serotonin transporter (5-HTT) availability and trait and state aggression, as well as response to the anti-aggressive effects of fluoxetine.

methodsWe examined 5-HTT availability using positron emission tomography (PET) imaging with [

resultsIn IED patients, trait aggression was positively associated with [

conclusionsConsistent with prior reports, ACC 5-HTT is related to trait aggression, and adjusting for factors related to proactive (callousness) and reactive (childhood trauma) aggression subtypes further resolves this relationship. Novel findings of the study include a better understanding of the association between regional 5-HTT availability and state aggression, and the involvement of VST 5-HTT with trait aggression, and with the anti-aggressive effects of fluoxetine.

Indexed as

FluoxetineSerotonin Plasma Membrane Transport ProteinsAggressionHumansPersonalityPersonality DisordersPositron-Emission TomographyFluoxetineSerotonin Plasma Membrane Transport ProteinsAggressionAnterior cingulate cortexCallousnessChildhood traumaDASBFluoxetineIntermittent explosive disorderPositron emission tomographySerotonin transporterVentral striatum

Identifiers

PMID36640190
PMCPMC13426369
OpenAlexW4316042180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.