ArticleBrain and behavior2023
Behavioral outcome of very preterm children at 5 years of age: Prognostic utility of brain tissue volumes at term-equivalent-age, perinatal, and environmental factors.
Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Regional Brain Volume Differences Were Associated With Behavioural Outcomes in Children Born Preterm: A Systematic Review.Acta paediatrica (Oslo, Norway : 1992) · 2026Pooled it
- Critical Methodological Gaps in Brain Volume Review: A Reader's Perspective?Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Cognition, internalizing symptoms and neonatal cingulate-amygdala interaction in children born very low birth weight.Frontiers in pediatrics · 2026Article
- Neonatal amygdala volumes, procedural pain and the association with social-emotional development in children born very preterm.Brain structure & function · 2024Article
- Amygdala volumes and associations with socio-emotional competencies in preterm youth: cross-sectional and longitudinal data.Pediatric research · 2024Article
- Amygdala structure and function and its associations with social-emotional outcomes in a low-risk preterm sample.Brain structure & function · 2024Article
- Short-term outcomes in early term infants (born at 37 or 38 weeks): a retrospective investigation.Frontiers in pediatrics · 2024Article
- Predicting risk of preterm birth in singleton pregnancies using machine learning algorithms.Frontiers in big data · 2024Article
- Relationship of early brain growth pattern measured by ultrasound with neurological outcome at two years of age in very low birth weight infants.European journal of pediatrics · 2023Article
- Prenatal exposure to air pollution is associated with structural changes in the neonatal brain.Environment international · 2023Article
- Behavioral outcome of very preterm children at 5 years of age: Prognostic utility of brain tissue volumes at term-equivalent-age, perinatal, and environmental factors.Brain and behavior · 2023Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivePrematurity is associated with a high risk of long-term behavioral problems. This study aimed to assess the prognostic utility of volumetric brain data at term-equivalent-age (TEA), clinical perinatal factors, and parental social economic risk in the prediction of the behavioral outcome at 5 years in a cohort of very preterm infants (VPT, <32 gestational weeks).
methodsT2-weighted magnetic resonance brain images of 80 VPT children were acquired at TEA and automatically segmented into cortical gray matter, deep subcortical gray matter, white matter (WM), cerebellum (CB), and cerebrospinal fluid. The gray matter structure of the amygdala was manually segmented. Children were examined at 5 years of age with a behavioral assessment, using the strengths and difficulties questionnaire (SDQ). The utility of brain volumes at TEA, perinatal factors, and social economic risk for the prediction of behavioral outcome was investigated using support vector machine classifiers and permutation feature importance.
resultsThe predictive modeling of the volumetric data showed that WM, amygdala, and CB volumes were the best predictors of the SDQ emotional symptoms score. Among the perinatal factors, sex, sepsis, and bronchopulmonary dysplasia were the best predictors of the hyperactivity/inattention score. When combining the social economic risk with volumetric and perinatal factors, we were able to accurately predict the emotional symptoms score. Finally, social economic risk was positively correlated with the scores of conduct problems and peer problems.
conclusionsThis study provides information on the relation between brain structure at TEA and clinical perinatal factors with behavioral outcome at age 5 years in VPT children. Nevertheless, the overall predictive power of our models is relatively modest, and further research is needed to identify factors associated with subsequent behavioral problems in this population.
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