ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
Quantitative Fluorescence Analysis Reveals Dendrite-Specific Thalamocortical Plasticity in L5 Pyramidal Neurons during Learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
- Association learning drives synaptic plasticity at feedforward synapses in somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Sexually dimorphic plasticity of PV inhibition in sensory neocortex during learning.Scientific reports · 2026Article
- Long-lasting, subtype-specific regulation of somatostatin interneurons during sensory learning.Science advances · 2025Article
- Learning, prediction accuracy, and neural plasticity in sensory cortex.Current opinion in neurobiology · 2025Review
- Article
- Transient Inhibition of the Mediodorsal Thalamus During Early Adolescence Induces Hypofrontality and Social Memory Deficits in Young Adulthood.Biological psychiatry global open science · 2025Article
- Somatostatin neurons detect stimulus-reward contingencies to reduce neocortical inhibition during learning.Cell reports · 2025Article
- Combining nanobody labeling with STED microscopy reveals input-specific and layer-specific organization of neocortical synapses.PLoS biology · 2025Article
- Early hippocampal hyperexcitability and synaptic reorganization in mouse models of amyloidosis.iScience · 2024Article
- Goal-directed learning is multidimensional and accompanied by diverse and widespread changes in neocortical signaling.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Goal-Directed Learning is Multidimensional and Accompanied by Diverse and Widespread Changes in Neocortical Signaling.bioRxiv : the preprint server for biology · 2024Article
- Transient enhancement of stimulus-evoked activity in neocortex during sensory learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Article
- Dendritic Spines: Synaptogenesis and Synaptic Pruning for the Developmental Organization of Brain Circuits.Advances in neurobiology · 2023Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
High-throughput anatomic data can stimulate and constrain new hypotheses about how neural circuits change in response to experience. Here, we use fluorescence-based reagents for presynaptic and postsynaptic labeling to monitor changes in thalamocortical synapses onto different compartments of layer 5 (L5) pyramidal (Pyr) neurons in somatosensory (barrel) cortex from mixed-sex mice during whisker-dependent learning (Audette et al., 2019). Using axonal fills and molecular-genetic tags for synapse identification in fixed tissue from Rbp4-Cre transgenic mice, we found that thalamocortical synapses from the higher-order posterior medial thalamic nucleus showed rapid morphologic changes in both presynaptic and postsynaptic structures at the earliest stages of sensory association training. Detected increases in thalamocortical synaptic size were compartment specific, occurring selectively in the proximal dendrites onto L5 Pyr and not at inputs onto their apical tufts in L1. Both axonal and dendritic changes were transient, normalizing back to baseline as animals became expert in the task. Anatomical measurements were corroborated by electrophysiological recordings at different stages of training. Thus, fluorescence-based analysis of input- and target-specific synapses can reveal compartment-specific changes in synapse properties during learning.
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