ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
Neural Contributions to Reduced Fluid Intelligence across the Adult Lifespan.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Harnessing Brain Age-Specific Effects on the Associations Between Sleep Quality, Glymphatic Function, and Cognition in Normal Ageing Adults: Insights for Gerotherapeutics.Neurology and therapy · 2026Article
- Preserved topography, lateralization, selectivity, and functional connectivity of the language network in older brains.Nature communications · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Neuroimaging Correlates of the NIH Toolbox Cognition and Trail Making Tests: Normative Benchmarks in Healthy Aging.Clinical and translational neuroscience · 2026Article
- Exploring the "Tip of the Tongue" and "Feeling of Knowing" Phenomena During Advanced Aging: The Interplay of Age of Acquisition, Vocabulary and Verbal Fluency.Behavioral sciences (Basel, Switzerland) · 2025Article
- Cerebral cortical structures linked to intelligence.bioRxiv : the preprint server for biology · 2025Article
- Article
- Study protocol: The efficacy of mushroom to prevent cognitive decline in at-risk middle-aged adults and young-olds living in the community.Frontiers in aging neuroscience · 2025Article
- Cognitive flexibility in aging: the impact of age range and task difficulty on local switch costs in task switching.Frontiers in aging neuroscience · 2025Article
- Linguistic inputs must be syntactically parsable to fully engage the language network.bioRxiv : the preprint server for biology · 2024Article
- Reorganization of structural connectivity in the brain supports preservation of cognitive ability in healthy aging.Network neuroscience (Cambridge, Mass.) · 2024Article
- Analysis of Resting-State Functional Magnetic Resonance Imaging in Alzheimer's Disease.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The Development of a Pilot App Targeting Short-Term and Prospective Memory in People Diagnosed with Dementia.Behavioral sciences (Basel, Switzerland) · 2023Article
- Individual Variability in Performance Reflects Selectivity of the Multiple Demand Network among Children and Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Multiple brain activation patterns underlying successful visual short-term memory across the adult lifespan.Imaging neuroscience (Cambridge, Mass.)Article
- The Inverted U: Exploring the Interconnectedness of Movement and Cognitive Function Across the Lifespan.Wiley interdisciplinary reviews. Cognitive scienceReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Fluid intelligence, the ability to solve novel, complex problems, declines steeply during healthy human aging. Using fMRI, fluid intelligence has been repeatedly associated with activation of a frontoparietal brain network, and impairment following focal damage to these regions suggests that fluid intelligence depends on their integrity. It is therefore possible that age-related functional differences in frontoparietal activity contribute to the reduction in fluid intelligence. This paper reports on analysis of the Cambridge Center for Ageing and Neuroscience data, a large, population-based cohort of healthy males and females across the adult lifespan. The data support a model in which age-related differences in fluid intelligence are partially mediated by the responsiveness of frontoparietal regions to novel problem-solving. We first replicate a prior finding of such mediation using an independent sample. We then precisely localize the mediating brain regions, and show that mediation is specifically associated with voxels most activated by cognitive demand, but not with voxels suppressed by cognitive demand. We quantify the robustness of this result to potential unmodeled confounders, and estimate the causal direction of the effects. Finally, exploratory analyses suggest that neural mediation of age-related differences in fluid intelligence is moderated by the variety of regular physical activities, more reliably than by their frequency or duration. An additional moderating role of the variety of nonphysical activities emerged when controlling for head motion. A better understanding of the mechanisms that link healthy aging with lower fluid intelligence may suggest strategies for mitigating such decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.