Evidence map›Paper›PMID 36639898›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Indirect Effects of Halorhodopsin Activation: Potassium Redistribution, Nonspecific Inhibition, and Spreading Depolarization.

R Ryley Parrish, Connie MacKenzie-Gray Scott, Tom Jackson-Taylor, Alex Grundmann, Faye McLeod, Neela K Codadu, Alexandru Călin, Hannah Alfonsa, Rob C Wykes, Juha Voipio and 1 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Contrasting roles of secondary motor cortex projections to the dorsolateral and dorsomedial striatum in incubation of cocaine-seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  3. Review
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  8. On brain stimulation in epilepsy.Brain : a journal of neurology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Inhibition of Dopamine Neurons Prevents Incentive Value Encoding of a Reward Cue: With Revelations from Deep Phenotyping.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

R Ryley ParrishNewcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom.
Connie MacKenzie-Gray ScottNewcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom.
Tom Jackson-TaylorNewcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom.
Alex GrundmannNewcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom.
Faye McLeodNewcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom.
Neela K CodaduQueen Square Institute of Neurology, University College London, WC1N 3BG, United Kingdom.
Alexandru CălinNewcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom.ORCID 0000-0003-2363-2898
Hannah AlfonsaNewcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom.
Rob C WykesNanomedicine Lab, University of Manchester, Manchester, M13 9PL, United Kingdom.ORCID 0000-0002-6141-6822
Juha VoipioFaculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences, University of Helsinki, Helsinki, 00014, Finland.
Andrew J TrevelyanNewcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom andrew.trevelyan@ncl.ac.uk.ORCID 0000-0001-9307-4241
Newcastle University · GBQueen Mary University of London · GBBrigham Young University · USUniversity of Helsinki · FI

Funding

Biotechnology and Biological Sciences Research Council BB/P019854/1Department of HealthMedical Research Council MR/R005427/1Wellcome Trust 206500/Z/17/Z
6 · The paper itself

Abstract

The movement of ions in and out of neurons can exert significant effects on neighboring cells. Here we report several experimentally important consequences of activation of the optogenetic chloride pump, halorhodopsin. We recorded extracellular K

Indexed as

Cortical Spreading DepressionPotassiumAnimalsChloridesFemaleHalorhodopsinsMaleMiceNeuronsPyramidal CellsChloridesHalorhodopsinsPotassiumchloridehalorhodopsinpotassiumpyramidal cellsspreading depression

Identifiers

PMID36639898
PMCPMC9899079
OpenAlexW4312058955

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.