ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions.
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Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Interplay of GBA1 with lysosomal dysfunction and inflammation in Parkinson's disease.Neural regeneration research · 2026Article
- Neurodegenerative diseases and immune system: From pathogenic mechanism to therapy.Neural regeneration research · 2026Article
- Lysine acetyltransferase 8-mediated histone acetylation, regulated by GBA1, is associated with lysosomal function related to α-Synuclein pathology.Cell death & disease · 2026Article
- Glucosylceramide-induced ectosomes propagate pathogenic α-synuclein in Parkinson's disease.Nature cell biology · 2026Article
- Multi-omics insights into GBA1-associated Parkinson's disease: interplay of genomics, transcriptomics, proteomics, and lipidomics.Molecular neurodegeneration · 2026Review
- Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models.Journal of neuroinflammation · 2025Article
- Synaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson's disease and dementia with Lewy bodies.Nature communications · 2025Article
- Elevated hexosylceramides in Parkinson's disease cause gene upregulations in neurons mimicking responses to pathogens.NPJ Parkinson's disease · 2025Article
- Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice.JCI insight · 2025Article
- A novel allosteric GCase modulator prevents Tau accumulation in GBA1Scientific reports · 2025Article
- Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation.Brain : a journal of neurology · 2025Article
- Alpha-Synuclein Pathophysiology in Neurodegenerative Disorders: A Review Focusing on Molecular Mechanisms and Treatment Advances in Parkinson's Disease.Cellular and molecular neurobiology · 2025Review
- Article
- Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidase.NPJ Parkinson's disease · 2024Article
- Effects ofInternational journal of molecular sciences · 2024Article
- Lysosomal dysfunction in α-synuclein pathology: molecular mechanisms and therapeutic strategies.Cellular and molecular life sciences : CMLS · 2024Review
- Suppression of the JAK/STAT pathway inhibits neuroinflammation in the line 61-PFF mouse model of Parkinson's disease.Journal of neuroinflammation · 2024Article
- Gaucher disease provides a unique window into Parkinson disease pathogenesis.Nature reviews. Neurology · 2024Review
- Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy.NPJ Parkinson's disease · 2024Article
- Suppression of the JAK/STAT Pathway Inhibits Neuroinflammation in the Line 61-PFF Mouse Model of Parkinson's Disease.Research square · 2024Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Casey L Mahoney-CraneCenter for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama 35294.ORCID 0000-0002-6142-3627
Megha ViswanathanCenter for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Dreson RussellCenter for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Rachel A C CurtissCenter for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Jennifer FreireCenter for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Sai Sumedha BobbaCenter for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Sean D CoyleCenter for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Monika KandeboNeuroscience Discovery, Merck & Company, Inc, West Point, Pennsylvania 19486.
Lihang YaoNeuroscience Discovery, Merck & Company, Inc, West Point, Pennsylvania 19486.
Bang-Lin WanNeuroscience Discovery, Merck & Company, Inc, West Point, Pennsylvania 19486.
Nathan G HatcherNeuroscience Discovery, Merck & Company, Inc, West Point, Pennsylvania 19486.
Sean M SmithNeuroscience Discovery, Merck & Company, Inc, West Point, Pennsylvania 19486.
Jacob N MarcusNeuroscience Discovery, Merck & Company, Inc, West Point, Pennsylvania 19486.
Laura A Volpicelli-DaleyCenter for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama 35294 lvolpicellidaley@uabmc.edu.
University of Alabama at Birmingham · USUnited States Military Academy · US
Funding
Role of presynaptic targeting of alpha-synuclein in the pathogenesis of Parkinson's Disease and Dementia with Lewy BodiesR01NS102257 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VOLPICELLI-DALEY, LAURA A. · 2018 to 2022
$1.9MUAB Training Program In NeuroscienceT32NS095775 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Erik D Roberson · 2017 to 2026
$1.6MAlpha-synuclein aggregate induced synapse loss is a pathological event contributing to Lewy body dementiasR56NS117465 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VOLPICELLI-DALEY, LAURA A. · 2020 to 2020
$769kThe effect of GBA1 L444P heterozygous mutation on synaptic morphology in the hippocampus and cognition related to Lewy body dementiasF31NS129277 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MAHONEY-CRANE, CASEY · 2022 to 2023
$77kNINDS NIH HHS F31 NS129277NINDS NIH HHS R01 NS102257NINDS NIH HHS R56 NS117465NINDS NIH HHS T32 NS095775
Abstract
The most common genetic risk factor for Parkinson's disease (PD) is heterozygous mutations
Indexed as
alpha-SynucleinGlucosylceramidaseParkinson DiseaseSynucleinopathiesAnimalsHippocampusMiceMutationPsychosinealpha-SynucleinGlucosylceramidasePsychosinesphingosyl beta-glucosideglucocerebrosidaseglucosylceramideglucosylsphingosineParkinson's diseasevenglustatα-synuclein
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.