ArticleBMC oral health2023
The antimicrobial efficacy of graphene oxide, double antibiotic paste, and their combination against Enterococcus faecalis in the root canal treatment.
Article in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Antibacterial efficacy of quaternary ammonium compounds (QACs) against Enterococcus faecalis in endodontic infections: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Synthesis, Characterisation and Antibacterial Activity of Reduced Graphene Oxide-Cuprous Oxide Nanocomposite Against Dual Species Biofilms Using Clsm.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Bioinspired 8‑hydroxyquinoline-FeScientific reports · 2026Article
- Evaluation of EDTA and silver nanoparticle based root canal irrigants on smear layer elimination and dentine surface roughness.Bioinformation · 2026Article
- A Novel Synergistic Carvacrol-Graphene Oxide-Chitosan Nanocomposite for Effective Root Canal Disinfection.International journal of dentistry · 2026Article
- Effect of graphene-based intracanal medicament on push-out bond strength of different endodontic sealers in root canal dentin - an in vitro study.Biomaterial investigations in dentistry · 2026Article
- Antimicrobial efficacy of methylene blue-functionalized graphene oxide-mediated photodynamic therapy againstJournal of Taibah University Medical Sciences · 2025Article
- Antimicrobial efficacy of methylene blue-functionalized graphene oxide-mediated photodynamic therapy againstJournal of Taibah University Medical Sciences · 2025Review
- Comparative Analysis of Fracture Resistance in Teeth Obturated with Graphene Oxide-Modified Sealers.Journal of pharmacy & bioallied sciences · 2025Article
- Dual acid-base catalysis with biologically modified graphene oxide: a sustainable route to polyhydroquinolines with antimicrobial properties.Scientific reports · 2025Article
- Synthesis, characterization, and application of methylene blue functionalized reduced graphene oxide for photodynamic therapy in root canal treatment.Pakistan journal of medical sciences · 2025Article
- Microstructural characterization, mechanical and microbiological properties of acrylic resins added with reduced graphene oxide.Odontology · 2025Article
- Article
- EradicatingJournal of dental sciences · 2024Article
- Review
- Applications of graphene oxide and reduced graphene oxide in advanced dental materials and therapies.Journal of Taibah University Medical Sciences · 2024Review
- Graphene as a promising material in orthodontics: A review.Journal of orthodontic science · 2024Review
- The effect of nanobased irrigants on the root canal dentin microhardness: an ex-vivo study.BMC oral health · 2023Article
- Bactericidal Activity of Graphene Oxide Tests for Selected Microorganisms.Materials (Basel, Switzerland) · 2023Article
- The antimicrobial efficacy of nanographene oxide and double antibiotic paste per se and in combination: part II.BMC oral health · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundInter-appointment medication of the root canals with appropriate intracanal medicaments has been advocated to improve root canal disinfection. Graphene oxide (GO) has shown promising antimicrobial activity against a wide range of microorganisms, besides the capability of carrying antibiotics. The current study aimed to compare the antibacterial activity of double antibiotic paste (DAP) and GO per se and in combination (GO-DAP) against Enterococcus faecalis (E. faecalis).
methodsA total of 108 extracted human mandibular premolars were contaminated with three-week-old E. faecalis and subjected to a primary microbial assessment. The samples were categorized into 15 groups concerning the intracanal medicament (DAP, GO, GO-DAP, and control) and contact time (1, 7, and 14 days). Then, the root canals were medicated, incubated, and resubjected to a secondary antimicrobial evaluation. The colony-forming units (CFU) were counted to calculate the antimicrobial efficacy. The data were analyzed via the Kruskal-Wallis test (α = 0.05).
resultsGO-DAP was the only medicament that completely eradicated E. faecalis in 1 day. The percentage reduction of CFU/ml in the GO-DAP and DAP groups was higher than that in the GO group at all allocated contact times. Furthermore, a significant decrease of the CFU/ml was seen in the GO and DAP groups after 7 and 14 days of being medicated (P < 0.05).
conclusionSince GO-DAP improved root canal disinfection, this novel material can be introduced as a promising intracanal medicament against E. faecalis even in the short run.
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