Evidence map›Paper›PMID 36639617›Full record

ArticleBMC neurology2023

Ultrasound measurement of optic nerve sheath diameter in a healthy adult Colombian population.

Guillermo Trocha, Andrés Bonilla, Camilo Romero, Jonathan Palacios, Nicolas Molano-Gonzalez

Registry-linked trialAbstract read
In one paragraph

Article in BMC neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07786324 (Comparison of 3% Hypertonic Saline Versus 20% Mannitol in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Optic Nerve Sheath Diameter Measurements''), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07786324 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Comparison of 3% Hypertonic Saline Versus 20% Mannitol in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Optic Nerve Sheath Diameter Measurements''

TypeinterventionalSponsorAssiut UniversityRan2026 to 2029Enrolled100ConditionsTBI (Traumatic Brain Injury), ICP (Intracranial Pressure) Increase, Optic Nerve Sheath Diameter MeasurementArmsMannitol (20%), Hypertonic Saline ( 3% Sodium Chloride Saline)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Optic Nerve Sheath Diameter: Which Axis Should Be Measured?Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guillermo TrochaDepartment of Neurology, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.
Andrés BonillaDepartment of Neurology, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.
Camilo RomeroDepartment of Neurology, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.
Jonathan PalaciosDepartment of Critical Care Medicine, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.
Nicolas Molano-GonzalezClinical Research Group, School of Medicine and Health Science, Universidad del Rosario, Bogotá, Colombia. nicolas.molano@urosario.edu.co.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMeasurement of the optic nerve sheath diameter (ONSD) provides a rapid, safe, and easy method for detecting increased intracranial pressure (ICP). However, the normal mean and upper limit values may vary according to sex, age, ethnicity, and ultrasound technique.

aimWe aimed to obtain the mean ONSD in a healthy Colombian adult population and to correlate it with demographic and anthropometric measures.

methodsIn a prospective study using a 10-13 MHz linear ultrasound probe, eye transverse diameter (ETD) and ONSD in the transverse (ONSD-TP) and sagittal planes (ONSD-SP) were measured in healthy adult volunteers in Bogota, Colombia.

resultsA total of 100 healthy subjects were included, with a mean age of 26,7 ± 8,3 years and 62 women. The mean ETD, ONSD-TP and ONSD-SP was 23.11 mm (95% confidence interval (CI): 22.90 mm-23.32 mm), 3.96 mm (95% CI: 3.85 mm-4.07 mm) and 4.0 mm (95% CI: 3.90 mm-4.11 mm), respectively. The ONSD in both planes ranged from 2.35 mm to 5.20 mm. There was a significant correlation between ONSD-SP and ONSD-TP (p < 0.0001) but no correlation between the ocular measures and demographic or anthropometric variables (p > 0.05). The intraclass correlation between the eyes was statistically significant.

conclusionOur study shows that ultrasound-measured ONSD in healthy adults in Colombia is similar to that found worldwide. An ONSD of 5.5 mm may be considered the upper limit for healthy adults in Colombia. ONSD can be measured in either plane; there is a good correlation between the two eyes; and ONSD is not modified by demographic or anthropometric characteristics.

Indexed as

Intracranial HypertensionOptic NerveAdultColombiaFemaleHealthy VolunteersHumansInfant, NewbornIntracranial PressureProspective StudiesUltrasonographyHealthy AdultsLatin AmericaOptic nerve sheath diameterUltrasonography

Identifiers

PMID36639617
PMCPMC9837461

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.